Prostate Cancer Research Group (SAHMRI)
Our internationally-recognised research is tackling localised and metastatic prostate cancer by developing more robust diagnostics tests, biomarkers for responsiveness to current treatments and new drugs for clinical development.
Prostate cancer is a major public health issue, killing approximately 3,300 men in Australia annually. While early stage cancers can be treated with surgery, advanced and metastatic cancers are treated with drugs which block the actions of male hormones, known as androgens. Androgens, such as testosterone and dihydrotestosterone, are critical for normal prostate development and for the growth of prostate cancers. While drugs which target androgen pathways in prostate cancer cells are initially effective, patients eventually relapse and progress to an incurable stage of the disease. More research is needed to improve outcomes for prostate cancer patients.
Our research aims to not only determine the effectiveness of new drugs undergoing clinical development but also to develop robust diagnostic tests to better predict cancer behaviour and assess response to treatment with existing and new prostate cancer drugs. A major focus of these efforts is the lipid metabolic pathway which our group is trying to better understand and exploit to improve outcomes for men with prostate cancer.
To achieve this, we have developed a unique patient-derived explant (PDE) model, which improves the clinical relevance of our data, and increases the likelihood that our research findings will quickly translate to clinical practice.
Read the latest news at the Prostate Cancer Research Group's blog.
Professor Lisa Butler
Professor Lisa Butler is a Cancer Council Principal Research Fellow in the Adelaide Medical School at the University of Adelaide, and heads the Prostate Cancer Research Group at the South Australian Health and Medical Research Institute (SAHMRI). A major focus of her research program during the past five years has been the development of preclinical models that more closely represent the individual responses in men with prostate cancer.
Research team Role Dr Maggie Centenera Researcher Dr Nicole Moore Researcher Dr Zeyad Nassar Researcher Swati Irani Research support Joanna Gillis Research support Maud Giles Research support Natalie Ryan Research support Kayla Bremert Research support Madison Helm Research support Cassandra Gordon Research support Samira Khabbazi Research support Dr Adel Aref - PhD candidate Student Shadrack Mutuku - PhD candidate Student Josephine Hinneh - PhD candidate Student Chui Yan (Shanice) Mah - PhD candidate Student Julia Scott - PhD candidate Student Deanna Miller - MPhil candidate Student
- Chris O’Brien Lifehouse, New South Wales
- Olivia Newton John Cancer Research Institute, Victoria
- South Australian Health and Medical Research Institute
- University of Leuven, Belgium
- University of New South Wales
- University of Sydney
- University of South Australia
- Weill Cornell Medicine, USA
- Lipids and Prostate Cancer
Related areas of research
We offer exciting opportunities for researchers at the honours, masters and PhD levels. Our research degrees are open to students from a broad range of backgrounds, and range from basic sciences to clinical research. If you are interested in human health, consider furthering your research career with us.