Participate in Research

Would you like to be a part of ground breaking medical research? Researchers in our faculty frequently undertake clinical trials to test new medical treatments and interventions. Your participation is crucial to improving the health of our population. Explore our currently enrolling trials below.

What is a clinical trial, and why do we need them?

Clinical trials are research studies that involve human volunteers who are assigned to one or more health-related interventions to evaluate the effects on health outcomes. Clinical trials are essential for the development of new medical treatments and interventions. They are used to determine if a new intervention works, if it is safe, and whether or not it is an improvement on currently available treatments.

The following trials are currently seeking participants:

  • Brain rhythms and cognition in healthy ageing

    Participate in this study investigating how ageing affects brain rhythms during working memory, and how the brain deals with distracting information.

    You will need to attend our clinic in the Adelaide CBD for one session of approximately 2-2.5 hours to complete a safe and painless recording of brain activity, questionnaires, and a computer-based task.

    Participants will receive a $20 gift card honorarium after successful completion of the study.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 18-35 OR 60+
    • have not been diagnosed with dementia, or mild cognitive impairment (MCI)

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Sabrina Sghirripa
    Email: sabrina.sghirripa@adelaide.edu.au

    OR

    Rebecca Hanna
    Email: rebecca.hanna@adelaide.edu.au

  • Saliva lithium monitoring

    Patients taking lithium medication need to get regular blood tests to ensure they are on effective and safe dose. This study aims to look at whether we can reliably measure lithium levels in saliva, a much less invasive alternative to collecting blood. 

    Participants will be required to provide a blood through a blood draw and a saliva sample through drool collection. We will look at whether the lithium levels in both samples match each other. 

    Samples may be provided at a number of SA Health sites across Adelaide, or at the Adelaide Health and Medical Sciences building on North Terrace in the Adelaide CBD. A convenient location will be organised with participants once recruited for study.

    The sample collection will take between 30 minutes to 1 hour and participants will receive a $20 Coles/Myer gift voucher honorarium after successful completion of the study.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 18-65
    • are currently taking lithium medications

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Email: psychiatry_res@adelaide.edu.au
    Phone: (08) 8313 7676

  • Human neck stiffness and range of motion

    We are investigating the stiffness and range of motion of healthy human necks.

    The study will be a single three-hour session, conducted at the Adelaide Health and Medical Sciences building on North Terrace in the Adelaide CBD. During the test, participants will lie face down in our customised apparatus and perform a series of neck rotations with or without the help of a researcher. There will be sensors and reflective markers placed on the participant’s head, neck, and upper torso for motion tracking and muscle activation monitoring. 

    Upon successful completion of this study, participants will receive an honorarium of $60 in the form of a gift voucher.

    This study is categorised as low risk and has been approved by the Human Research Ethics Committee at the University of Adelaide.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 20-80
    • are in general good health
    • have had no neck pain in the last three months

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Mingyue Liu​​​​​​​
    Phone: (08) 8313 2852
    Email: mingyue.liu@adelaide.edu.au

  • Brain function and movement control in young and older adults

    We are looking for healthy volunteers to investigate how the brain functions to control skilled hand movements, its ability to change its connections (neuroplasticity), and how this changes with age.

    The study will involve an assessment of the pathway from the brain to the muscles by giving a series of brief (painless) magnetic pulses that make the hand twitch briefly. The electrical activity in these muscles is measured with electrodes placed on the skin. 

    Participants will be required to attend several (2 to 4) sessions at the Neurophysiology of Human Movement Laboratories on Level 4 of the Helen Mayo South Building on Frome Road in the Adelaide CBD. Each session will last from 2-3 hours participants will receive a $30 gift voucher honorarium for each successful session they complete.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 18-35 or 60-80 years
    • are right handed
    • have no history of neurological impairments (e.g. epilepsy) or brain injury
    • are not using medications that affect neurological function (e.g. antidepressants, sedatives, antipsychotics)
    • do not have a cardiac pacemaker

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Merrick Liao
    Email: wei-yeh.liao@adelaide.edu.au

  • Impact of placement of visual information in the visual field to the ability to navigate in the environment and deploy attention

    Augmented reality (AR) and virtual reality (VR) systems are becoming more prevalent in both our personal and working lives. However, we do not yet have a good understanding about how visual performance using these systems changes when we are interacting with the environment (standing or walking).

    This study will help us understand how the placement of visual information in an AR / VR setting may impact visual processing and the ability to perform movements, interact with the environment and to deploy attention, especially when you are sitting, standing, or walking.

    As part of this study, participants will be required to:

    • Complete one testing session of about two hours at the Gait Analysis Laboratory, located in the Adelaide Health and Medical Sciences building on North Terrace
    • Complete a pre-screen fitness test similar to the Australian Army basic entry requirements (including push-ups, sit-ups, and shuttle run)
    • Have their eye movements and body position recorded using special sensors / cameras 
    • Complete a visual processing task (on screen or in VR) while sitting, standing, or walking

    Upon successful completion of this study, participants will receive an honorarium of $50.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 18-50 years
    • are free from major visual deficits 
    • have a good understanding of the English language

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Active Vision Lab
    Telephone: (08) 8313 4321
    Email: activevisionlab1@gmail.com

  • Nutrients and gut function

    Factors that control food intake, sugar levels in our blood, and the function of the stomach and small intestine are complex, and our understanding of them is far from complete. People vary in their eating habits, and this may also affect their ability to maintain a healthy digestive and metabolic system, and a healthy body weight. The composition of the foods that we eat can play an important role in regulating these factors, thereby keeping us healthy. 

    Our studies investigate the effects of various dietary nutrients, and taste compounds, on factors such as the contractions of the gut wall, the rate at which a meal empties from the stomach, the release of intestinal hormones, and the blood glucose response to a meal.

    Upon successful completion of our studies, participants will receive an honorarium of up to $400 (dependent on the requirements of the particular study) via EFT transfer.

    Eligibility requirements

    Our research group is conducting a number of various studies with the following eligibility requirements. You may be eligible to participate in our studies if you are:

    • aged 18-60, healthy, BMI 19-25kg/m2

    • aged 18-70, type 2 diabetic (T2D), BMI 19-35kg/m2

    • a non-smoker

    • not pregnant, breastfeeding, or taking hormonal contraception

    • not vegan/vegetarian (consumption of a beef or tuna meal is required)

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Nutrients GI Research team
    Email: nutrientresearch@adelaide.edu.au (include 'T2 DIABETIC' or 'HEALTHY' in the email subject line)

  • Isolating sensory responses of magnetic brain stimulation

    Non-invasive brain stimulation is a research and clinical technique which allows researchers to stimulate the outer layers of the brain across skull in humans. This remarkable approach is used to understand how the brain works and is also used as a treatment for brain disorders like depression. In this study, we are investigating how we can improve the accuracy of delivering and measuring the brain's response to non-invasive brain stimulation.

    Participants are required to attend three sessions. In the first session, participants will undergo an MRI of their brain. In the next two sessions, participants will wear a cap with gel-filled electrodes. While wearing the cap, participants will receive magnetic pulses to stimulate their brain and we will measure the brain responses with the electrode cap. By modelling the results, we can assess the how well the stimulation is activating the brain, possibly leading to new and improved ways of delivering the stimulation for therapeutic purposes.

    As part of the study, participants will need to attend the South Australian Health & Medical Research Institute (SAHMRI) on North Terrace, Adelaide for an MRI lasting about 30 minutes. Then, the next two sessions (involving stimulation) will take place at the University of Adelaide Helen Mayo Building on Frome Road. Each session will take about 3 hours. Upon successful completion of the study, participants will be reimbursed with a $50 honorarium.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 18-50 years old

    • are right handed

    • have no previous brain injury.

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Lynton Graetz - Research Assistant
    Telephone: (08) 8313 1308
    Email: lynton.graetz@adelaide.edu.au

    OR

    Dr Nigel Rogasch
    Email: nigel.rogasch@adelaide.edu.au

  • Exercise-induced structural and functional brain changes in individuals with chronic neck pain

    In a recent study, we found several differences in the structural and functional characteristics of the brain between people with chronic neck pain and pain-free controls. We also found that exercise therapy appeared to have different effects on the brain in people with chronic neck pain.

    In this new study, we aim to investigate those exercise-induced brain changes in people with chronic neck pain. In order to do that, participants will have an MRI scan at baseline, then participate in an 8-week exercise program, and then have their follow-up MRI scan to assess specifically what effects physical exercise has on the brain in people with chronic neck pain. 

    It is widely acknowledged that exercise is important for maintaining a good physical and mental health, mood and cognition. The effectiveness on health outcomes in individuals with chronic pain, however, has shown to vary across different populations and different types of exercise. 

    Participants in this study will engage in an 8-week exercise program, delivered by a physiotherapist from myPhysioSA Payneham, and it is possible that you will experience positive effects on your health outcomes. Each participant will also undergo two 30-min brain MRI scans at the South Australian Health & Medical Research Institute (SAHMRI) on North Terrace, Adelaide. Participants can indicate they wish to receive images of their brain. Participants can choose to receive a plain language summary of the study results.

    All aspects of this study, including the physiotherapist-delivered exercise program and the brain MRI scans, are FREE – there are no costs involved for the participant.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • have chronic neck pain at moderate intensity (>12 weeks)
    • are aged 18-55 years 
    • currently have a low level of physical activity
    • are able to lie in an MRI scanner on your back for 30 minutes
    • are free from metal implants or pacemaker (or other MRI contraindicators)
    • have English proficiency level to understand Participant Information Sheet

    In addition to the above, you will be ineligible to participate in this study if you:

    • have a history of migraine headaches
    • have had surgery to the neck
    • have diabetes
    • are currently receiving treatment for your neck pain (e.g. physiotherapy, chiropractic, acupuncture, or similar) 
    • have comorbidities preventing from regular exercise
    • are pregnant or breastfeeding
    • are claustrophobic

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Dr Rutger de Zoete
    Email: rutger.dezoete@adelaide.edu.au (include 'NECK PAIN' in the email subject line)

  • Effects of neuromodulation on brain excitability, fatigability and motor performance following an isometric fatiguing exercise protocol

    Transcranial direct current stimulation (tDCS) is a neuromodulation technique that has been used previously to enhance fatigability and improve performance in simple motor tasks. However, its effect on brain excitability and motor performance after exercise in young and older adults is yet to be determined

    In this experiment, participants will receive three separate treatments of tDCS over a three-week period at the Helen Mayo South Building (Frome Road, Adelaide) and will be required to perform a sustained submaximal isometric fatiguing exercise of the elbow flexor muscles during each session. Brain excitability will be measured using transcranial magnetic stimulation (TMS), a painlesss non-invasive method of brain stimulation. Each session will last ~2.5 hrs and participants will be compensated $15 per hour in Coles/Myer gift cards as reimbursement for their time.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 18-35 or 60-85 years 
    • have no history of epilepsy or seizures
    • are not currently on any psychoactive medication such as antidepressants, antipsychotics, or sedatives
    • have no history of a stroke or metal implants in the skull
    • have no history of arthritis in the wrist or elbow
    • have no cardiac pacemakers

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Miss Lavender Otieno
    Email: lavender.otieno@adelaide.edu.au (include 'FATIGUING STUDY' in the email subject line)

  • Promoting healthy ageing with avocado extract

    In this study, we are investigating how an avocado extract may improve your blood glucose control and promote healthy ageing.

    Participants will be required to consume a fine ground, freeze dried avocado extract daily. This avocado extract works as a calorie restriction mimetic to encourage the health benefits led by daily caloric restriction, without reducing daily energy intake.

    As part of the study, you will need to attend one of our clinical research facilities on 6 separate occasions over a 12-week period at the South Australian Health & Medical Research Institute (SAHMRI) on North Terrace, Adelaide. Upon successful completion of the study, you will be reimbursed for your time with a $200 honorarium via direct EFT deposit.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 25-65 years
    • are obese (BMI 30-40kg/m2)

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Helen Checklin
    Telephone: (08) 8128 4860
    Email: dietstudy@adelaide.edu.au (include 'AVOCADO' in the email subject line)

  • Diet for dads sperm study

    This study aims to test whether improving nutrient intake of men who are obese can improve sperm quality, without the need for weight loss after 12 weeks of dietary intervention. 

    If you meet the study eligibility criteria and consent to participate, you will be scheduled for a first assessment in our clinical rooms, located in the Adelaide CBD at the Adelaide Health and Medical Sciences Building on North Terrace, which will approximately take 30 mins. This will include:

    • Online medical and sexual history questionnaires, 
    • Height, weight, waist circumference measurements, 
    • Body composition measurement by a body image analyser (BIA), 
    • Fasted whole blood sampling for measurements of glucose, cholesterol and triglycerides, 
    • Blood pressure, 
    • Semen analysis, 
    • Fitted with an actigraphy device (Actiwatch - wGT3X-BT) to monitor daily movements and sleep/awake patterns for a week. 
    • Provided information about how to record your 3-day food diaries on the mobile phone app Research Food Diary. 

    Following on from this appointment, you will be randomised into either a control or intervention group.

    If you are allocated to the control group, you will have meet with our clinical trials coordinator who will provide the Australian guidelines on healthy eating, exercise, sleep and alcohol intake plus give you a run-down of the requirements during the 12-week intervention. Following the 12-week intervention, men in the control will also have the opportunity to have an appointment with a clinical dietician for education and administering of nutrient diet plans. 

    If allocated to the intervention group you will be prescribed the CSIRO Total Wellbeing Diet for Men and be allocated to four appointments with a clinical dietician from the CSIRO over a period of 12-weeks for nutritional prescription and maintenance of body weight. 

    Additional requirements of men during the 12-week intervention include recording of 3-day food diaries (Research Food Diary) every 2 weeks (Baseline, 2, 4, 6, 8, 10, 12 weeks) and weekly at home measurements of body weight. 

    At each semen sample collection point (Week 1 and Week 12), you will receive a free semen analysis, and, once your participation in the study is completed (Week 12), you will receive a total of $150 in Coles/Myer gift vouchers to thank you for your participation.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are male
    • are aged 18-55 years
    • have BMI >30

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Nicola Mathews
    Email: nicola.mathews@adelaide.edu.au (include 'D4Ds' in the email subject line)

  • Night shift worker protein preload study

    In this study, we are investigating how a protein supplement at dinner time may improve your blood glucose control overnight.

    As part of the study, you will need to attend one of our clinical research facilities on 5 separate occasions over a 6-week period at the South Australian Health & Medical Research Institute (SAHMRI) on North Terrace, Adelaide. You will be reimbursed for your time with a $200 honorarium via direct EFT deposit after you have attended all sessions.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are female
    • are aged 35-65 years
    • are overweight or obese (BMI 28-35 kg/m2)
    • work night shifts (either in a rotating, permanent, or split shift schedule)

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Dr Amy Hutchison
    Telephone: (08) 8128 4862
    Email: dietstudy@adelaide.edu.au (include 'SHIFT' in the email subject line)

  • Sweet taste diabetes research trial

    The Intestinal Nutrient Sensing Group aims to investigate the way sugars enter the blood (from our food), and whether these uptake pathways in the gut can be targeted in new ways to better control blood sugar.

    Our group has the following clinical studies underway, involving type 2 diabetic volunteers.

    Study 1: Investigating a novel therapy to slow glucose entry into the blood, leading to improved control of blood glucose.

    Study 2: Investigating whether diet supplementation with a combination of artificial sweeteners, affects blood glucose control.

    Eligibility requirements

    You may be eligible to take part if you are:

    • aged 28-75 years of age
    • have type 2 diabetes, managed by diet or by metformin medication alone
    • without diabetes and healthy
    • not under any dietary restrictions (you will be required to consume a beef lasagne meal).

    To volunteer you must be willing to attend our clinic at SAHMRI and the Royal Adelaide Hospital on three separate occasions, over one month.

    Upon successful completion of the study, volunteers will receive a $200 gift voucher. This research is approved by the Royal Adelaide Hospital Ethics Committee.

    Contact details for registrations of interest

    If you would like to be involved in our research studies, please contact 8128 4863 or email sweetener@adelaide.edu.au to register your interest.

  • Effectiveness of two different diets to reduce the risk of chronic disease

    Chronic diseases, such as type 2 diabetes and cardiovascular disease, are an increasing problem in Australia and around the world, and partly linked to increased rates of obesity, together with sedentary lifestyles. These diseases are partially preventable by lifestyle management.

    We are interested in finding out how changing what you eat, or when you eat, can reduce the risk of type 2 diabetes.

    As part of the study, you will need to attend one of our clinical research facilities on 7 separate occasions over a 12-month period (total ~7 hours) at either:

    • The South Australian Health & Medical Research Institute (SAHMRI) on North Terrace, Adelaide SA, OR
    • The Exercise and Nutrition Research Program at ACU at 8-18 Brunswick Street, Fitzroy VIC

    As part of the study, you will also receive 5 nutrition consults with one of our researchers via telehealth. You will also be reimbursed $300 via EFT transfer for your time at the end of the study.

    Eligibility requirements

    You may be eligible to participate in this study if you:

    • are aged 35-70
    • are overweight (BMI=25-45kg/m2)
    • do not currently have diabetes

    After expressing interest in the study, you will be invited to complete an online screening questionnaire via a link to a secure database. This questionnaire will ask you about your diet, exercise and medical history.

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Adelaide
    Email: dietstudy@adelaide.edu.au (include 'DIET' in the email subject line)
    Telephone: (08) 8128 4219 (leave a message to receive a call back)

    Melbourne
    Email: wowstudy@acu.edu.au (include 'DIET' in the email subject line)
    Telephone: (08) 8128 4219 (leave a message to receive a call back)

  • Genetics and environment in brain development: a twin study

    Neurodevelopmental disorders like epilepsy, intellectual disability, autism and cerebral palsy affect the way your brain develops. Since people often have more than one neurodevelopmental disorder, scientists believe that they sometimes have a common cause.

    This study invites monozygotic (identical) twins who are differently affected by one or more of these disorders to participate. We want to understand the causes of the differences in these twin pairs.

    We hope that this will help us to predict babies at risk of developing a neurodevelopmental disorder, so that doctors can more closely watch these babies develop and design better therapies or treatments for them.

    For further information and eligibility requirements, visit the Neurodevelopmental Disorder Study page.

  • Investigating the relationship between inflammation and anxiety disorders

    This research is investigating the role of the immune system in anxiety disorders.

    Anxiety disorders are very common, and can affect people of all ages. There are a wide range of factors associated with anxiety disorders. Although research has shown increased activity of the immune system in depression and psychosis, there is little research examining immune activity in people with anxiety disorders.

    The project investigates the role of the immune system by measuring inflammatory markers (small proteins in the blood) and inflammatory marker genes over time, in individuals with and without anxiety disorders. The research involves an initial visit, and a follow-up visit six months later.

    Eligibility requirements

    The research team is looking for people who suffer from anxiety (either currently or in the past), as well as people who have never had an anxiety disorder. Study participants need to be 12 years of age or over.

    At the initial and the follow-up visit, there are interviews/questionnaires, as well as a blood sample collection (for measurement of inflammatory markers).

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Telephone: 8313 7676
    Email: psychiatry_res@adelaide.edu.au

  • Meditation and polycystic ovary syndrome

    Does meditation improve quality of life and coping in adolescents with polycystic ovary syndrome (PCOS)?

    Women and adolescents with PCOS are more likely to have reduced quality of life and anxiety and/or mood symptoms than women without PCOS. There are no studies in girls or young women evaluating strategies like meditation to improve quality of life.

    Transcendental Meditation ® (TM) is a type of meditation that is practised sitting comfortably with eyes closed. It is taught by certified teachers. TM improves stress levels in adults, and improves school behaviour and blood pressure in children and adolescents.

    The main aim of this study is to evaluate the effect of TM on quality of life and stress in adolescent girls and young women with PCOS. The secondary aim of this study is to assess the effects of TM on cortisol (a stress hormone in the body) and blood pressure.

    Eligibility requirements

    1. Females between 12 and 22 years of age diagnosed with PCOS by a medical practitioner.
    2. Females willing and able to participate in TM instruction and practice during the study.

    A $30 honorarium will be issued to offset expenses associated with attending the study. 

    Questionnaire only part of the study 

    This additional part of the study requires females with polycystic ovary syndrome (PCOS). This aspect of the study aims to understand mood and quality of life in adolescent females with PCOS.

    Eligibility requirements:

    1. Females between 12 and 22 years old diagnosed with PCOS by a medical practitioner.
    2. Females willing to complete three questionnaires (mood, quality of life in general and in relation to PCOS).

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Dr Alexia Pena
    Telephone: 8161 8134 or 0405 373 297
    Email: alexia.pena@adelaide.edu.au

  • Quality of life in healthy girls

    Quality of life and mental health are an increasingly important aspect of life. In particular, the quality of life and mental health of adolescents is important in better understanding the current situation and whether these factors differ across different populations, including those with health conditions. This study aims to find out more information about quality of life and mood in healthy adolescent girls and to compare the findings to girls who have specific health conditions, such as polycystic ovary syndrome.

     Eligibility requirements:

    1. Females between 12 and 22 years old who are healthy (i.e. do not have any medical condition that requires ongoing medical follow up).
    2. Females willing to complete two questionnaires about mood and quality of life. 

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Dr Alexia Pena
    Telephone: 8161 8134 or 0405 373 297
    Email: alexia.pena@adelaide.edu.au

  • Gestational diabetes and neurodevelopment

    Approximately 1 in 10 pregnant women in Australia will develop gestational diabetes mellitus (GDM) during pregnancy. GDM results in hyperglycaemia and chronic inflammation, and is associated with increased risk of childhood neurodevelopmental abnormalities including attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and impairments in motor control and cognition. 

    We are performing the first study investigating the possible neurophysiological effects of GDM in 11-15 year olds, with a focus on neuroplasticity. We are also examining the ‘cortisol awakening response’, or the rapid increase in cortisol levels following awakening. Cortisol is a hormone with important functions in metabolism, stress, and brain function.

    The findings of this study will improve our understanding of the mechanisms by which GDM affects the developing brain, and will assist in the development of methods for early identification and treatment of GDM in order to prevent adverse neurodevelopment outcomes in affected children.

    We are currently recruiting a 'control group' of participants whose mothers did not have GDM during their pregnancy.

    The study involves the use of non-invasive brain stimulation techniques and collection of saliva samples. The brain stimulation techniques are safe and painless and routinely used in research.

    Eligibility requirements

    We are currently seeking participants aged 11-15 years who are to be accompanied by their mothers. Participants should be healthy with no history of neurological impairment, and mothers should not have received a diagnosis of GDM during pregnancy.

    The study involves the collection of several saliva samples (used to measure cortisol) at home over two mornings, followed by a 1.5 hour appointment at the University of Adelaide’s Robinson Research Institute, 77 King William Road, North Adelaide. We will also require some basic information about your child, including their gestational age and birth weight.

    Contact details for registrations of interest

    For further information, or if you and your child would like to participate, please contact:

    Mr Jago Van Dam
    Email: jago.vandam@adelaide.edu.au
    Telephone: 8313 1326

  • Brain rhythms and cognition in healthy ageing

    Advancing age is associated with a progressive decline in short-term or 'working' memory abilities. The nerve cells of the human brain are constantly sending and receiving information, generating tiny electrical signals that are often called 'brain waves' or 'brain rhythm'. These brain rhythms play an important role in human behaviour, are linked to memory processes and are thought to change with age.

    In this project, we will use advanced non-invasive brain recording techniques to investigate the role of these brain rhythms in short-term memory in both younger and older adults.

    Experiments will include questionnaires, recordings of brain activity, and memory testing. The brain recording techniques are safe and painless and routinely used in memory research.

    This study requires attendance of one session of approximately 2 hours duration at the Clinical Research Facility on level 4 of the Adelaide Health and Medical Sciences Building, North Tce. Participants will be reimbursed for their time with a $20 gift voucher.

    Eligibility requirements

    You may be eligible for this study if you:

    • are aged 18-35 or 60-80 years
    • have no history of neurological impairments or brain injury
    • are not using medications that affect neurological function (e.g. antidepressants, sedatives, antipsychotics)

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Sabrina Sghirripa
    Email: sabrina.sghirripa@adelaide.edu.au
    Telephone: 8313 1307

    Dr Mitchell Goldsworthy
    Email: mitchell.goldsworthy@adelaide.edu.au
    Telephone: 8313 1323

  • Migraine blood rest research study

    Professors Paul Rolan and Mark Hutchinson of the Faculty of Health and Medical Sciences are undertaking a research project to see whether a new technology can be used as a blood test for the diagnosis of migraine.

    Eligibility requirements

    We are looking for both migraine patients and healthy participants for the study. During a single visit to the University of Adelaide's Adelaide Medical School on North Terrace, participants are asked to complete a questionnaire, undergo an interview, and have a 30mL blood sample taken. A gift voucher will be given to thank you for your time (less than one hour in total).

    Contact details for registrations of interest

    For further information, or if you would like to participate, email migraine_study@adelaide.edu.au.

  • Adolescents resisting the drinking culture

    Significant numbers of Australian adolescents consume alcohol, with almost two thirds of them doing so at risky levels. As a consequence, the consumption of alcohol by Australian adolescents remains a national concern. The aim of this study is to establish new insights in the social phenomenon of adolescent drinking in Australia by applying an alternative lens and exploring what influences adolescents’ decisions to abstain, refrain or consume alcohol at low risk levels.  This study is part of a PhD being conducted in the Adelaide Nursing School, with Associate Professor Lynette Cusack as the Principal Investigator and Sue Sharrad as the PhD candidate.

    As there is limited understanding of this phenomenon, this research is important for future health promotion and education strategy directions. 

    Eligibility requirements

    To be eligible for the study, participants must be male or female adolescents, aged between 14-19 years of age, and either an abstainer, or low risk consumer of alcohol or can describe experiences where they have refrained from alcohol consumption.  Study participants must be able to commit to an interview that may last one to two hours.

    Contact details for registration of interest

    Student researcher and PhD candidate Sue Sharrad at suzanne.sharrad@adelaide.edu.au or phone 0414 383 349.

    HREC Approval No: H-2016-217

  • Knee Function Study

    Help investigate ways to assess knee function following lower-leg fracture surgery.

    Eligibility requirements

    To be eligible for the study participants must:

    1. be aged between 18 and 65
    2. be able to understand written and spoken English
    3. not suffer from any existing musculoskeletal disorders associated with mobility problems or impaired functioning of the lower limbs.

    Participants will receive a $20 gift voucher. This study has been approved by the Research Ethics Committee of the Royal Adelaide Hospital. 

    More informtion and registration of interest

    For more information visit Knee Function Study

  • ENDIA - Australia's largest study into the causes of Type 1 Diabetes in childhood

    Type 1 Diabetes in children is twice as common as it was 20 years ago. To understand why, the ENDIA (Environmental Determinants of Islet Autoimmunity) Study (external link) is the world’s first to follow children from the pregnancy to determine what factors influence the development of type 1 diabetes (T1D).

    This national study aims to follow 1400 babies who have a first degree relative with T1D. The study assesses environmental exposures and how these protect from or trigger the onset of T1D. ENDIA is an observational study; there are no interventions and participation is low risk.

    Eligibility requirements

    Family members who meet the following criteria may be eligible for ENDIA:

    • Pregnant women with T1D
    • Men with T1D whose partner is pregnant
    • Pregnant women with an older child who has T1D
    • Babies less than 6 months of age who have a first degree relative with T1D.

    Contact details for registrations of interest

    To express your interest in the study contact ENDIA by email endia@adelaide.edu.au or via the website at www.endia.org.au (external link), or call our nurse coordinators directly: Adelaide - (08) 8161 7349; Brisbane – (07) 3163 1759; Geelong – 0478 336 610; Melbourne – (03) 9342 8641; Newcastle – 0408 162 559; Perth – (08) 9340 7974; Sydney – (02) 9832 9243; ALL OTHER AREAS – (08) 8161 8655.

    Recruitment continues into 2018. ENDIA also has a Regional Participation Program for those living too far from ENDIA sites to be able to participate from their home.

    ENDIA is also on Facebook (external link) for regular news and updates. Please like or share our posts to spread the word!

    This study has ethical approval and current funding from JDRF Australia and the Helmsley Charitable Trust.

  • Exenatide (once weekly) trial

    Exenatide BD (also known as Byetta) is a drug that is used to manage blood sugar (glucose) levels in people with type 2 diabetes. It is widely used today and is injected twice daily. One of the ways in which Byetta works is by slowing the rate of stomach emptying and thereby reducing blood sugar levels. A once weekly preparation of exenatide (Bydureon) has now been approved for use in Australia. We plan to evaluate the effect of this medication on the rate of stomach emptying in healthy subjects. This study will provide important information relating to the mechanism of action of this drug in the management of people with type 2 diabetes.

    Eligibility requirements

    To be eligible for the study, we are looking for healthy (non-diabetic) male and female participants between 55 and 70 years of age (females must be postmenopausal), and in general good health. Study participants are required to attend the Discipline of Medicine at the Royal Adelaide Hospital once a week for the 9 week duration of the exenatide QW (Bydureon) treatments. At the beginning and end of the 9 week period, participants will have their rate of stomach emptying measured using a non-invasive technique.

    Contact details for registrations of interest

    Study co-ordinators: Mrs Rachael Tippett and Ms Seva Hatzinikolas. Phone 0451 735 247 or email researchdiabetes@adelaide.edu.au

  • Imagination and ESP

    This study aims to find out about a particular form of extra-sensory perception (ESP) known as precognition (correctly predicting a future target photograph from a set of five before the target is selected by a random number generator).

    You will be required to complete a few questionnaires. This will be done in person at the School of Psychology. This should all take no longer than 30 to 40 minutes. Participants may also find benefit in contributing to potentially valuable psychological research, as well as gaining experience and knowledge in methods of psychological testing.

    Eligibility requirements

    In order to be eligible for participation in this study, you must be 18 years or over, and be able to speak/read English fluently.

    Contact details for registrations of interest

    Dr Lance Storm
    Text “ESP” to 0437 032 556
    Email lance.storm@adelaide.edu.au with the subject “ESP”

    Dr Storm will respond as soon as possible with office location and available testing times.

  • MAGENTA: Magnesium sulphate at 30 to 34 weeks' gestational age: Neuroprotection trial

    Babies born very preterm have a greater risk of significant morbidities including neurologic impairments such as cerebral palsy. The risk of morbidity increases with decreasing gestational age at birth. The Cochrane review evaluating the effect of magnesium sulphate on neuroprotection of the fetus shows that magnesium sulphate given to women at risk of imminent preterm birth reduces the risk of cerebral palsy. It remains unclear at which gestational age treatment will be beneficial.

    The National Clinical Practice Guidelines on Antenatal Magnesium Sulphate prior to preterm birth of the fetus, infant and child recommends further randomised trials at 30 weeks' gestation or more. This had led to the MAGENTA Study.

    Chief Investigators: Professor Caroline Crowther, Philippa Middleton, Associate Professor Dominic Wilkinson, Associate Professor Ross Haslam

    Clinical Trial Coordinator: Pat Ashwood, Daniela Gagliardi, Michaela Jarrett

    Email: magenta@adelaide.edu.au

    Phone:+61 8 8161 7767

    ACTRN12611000491965

  • Mind and brain research at SAHMRI

    If you have encountered depression, anxiety, stress or chronic fatigue in your daily life, consider contributing to research at SAHMRI (external link)

  • GLP-1 for lowering plasma glucose in patients with type 2-diabetic patients

    This study compares the effects of a gut hormone called glucagon-like peptide-1 (GLP-1), when given by either intravenous or subcutaneous infusion. We aim to provide an optimal therapeutic effect with minimal adverse consequences, by comparing different delivery methods of a glucose lowering hormone GLP-1. 

    After successfully completing the trial, a minimum of $360 is paid via EFT transfer  to participants as an honorarium for their time.

    Eligibility requirements

    To be eligible for this study, you should be:

    • diagnosed with Type 2 diabetes without any other significant illness 
    • on long acting type insulin except (degludec)
    • aged 18-79 years
    • have a 20-35kg/m2 BMI

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Michelle Bound
    Telephone: (08) 8313 6676
    Email: diabetes@adelaide.edu.au

  • Can loss of response to the gut hormone, GIP, be reversed in type 2 diabetes?

    The gut hormone, glucose-dependent insulinotropic polypeptide (GIP), stimulates insulin secretion after meals, lowering blood glucose but it tends to be ineffective in people with type 2 diabetes. We are using a GIP antagonist to determine whether its glucose-lowering effect can be improved when type 2 diabetes is tightly controlled by 12 weeks of the oral anti-diabetic drug, called sitagliptin. We will evaluate the effects of GIP (using the GIP antagonist) at both the beginning and end of the intervention, by the use of an intraduodenal glucose infusion.

    After successfully completing the trial, a minimum of $400 is paid via EFT transfer to participants as an honorarium for their time.

    Eligibility requirements

    To be eligible for this study, you should be:

    • diagnosed with Type 2 diabetes (diet controlled or metformin only)
    • on long acting type insulin except (degludec)
    • aged 18-79 years
    • have a 20-35kg/m2 BMI
    • NOT taking Sitagliptin (DPP-IV Inhibitor) medication

    Contact details for registrations of interest

    For further information, or if you would like to participate, please contact:

    Michelle Bound
    Telephone: (08) 8313 6676
    Email: diabetes@adelaide.edu.au

  • Cognitive function across the lifespan

    Adult volunteers are needed for a research project investigating how general cognitive function changes with age. We know that many aspects of cognitive function are to some extent determined by our genetics. Genes (DNA) that affect the expression of certain chemicals and receptors in the brain influence our ability to perceive and process information in our environment, form new memories, and make decisions.

    This project will try to further refine our understanding of how our genetics influences our cognitive function across our lifespan. This project will lead to a deeper understanding of how cognitive function evolves over the course of healthy ageing, and could eventually lead to the development of a tool that could use information about an individual’s genetics to predict how their cognitive function may change over their lifespan. Importantly, this could help to identify individuals who are at risk for cognitive decline or dementia earlier, which could ultimately lead to more successful therapeutic interventions.

    What do participants have to do?

    • Complete a 30-minute online questionnaire www.borrowmybrain.org
    • Attend a face-to-face session of approximately 2.5 hours duration at our city-based laboratory, which involves:
      • A series of tests of general cognitive function (memory, vocabulary, attention)
      • A saliva sample, which will be used for DNA testing in order to determine whether genotypes that influence neurological functioning are related to cognitive function.

    (All tests are non-invasive and should cause no discomfort).

    Honorarium

    Participants will receive a $50 Coles Myer gift card on completion of the survey and laboratory visit.

    Eligibility requirements

    We are looking for healthy participants who are:

    • aged 18 years or older
    • fluent English speakers
    • not diagnosed with a neurological disorder and with no prior history of brain injury
    • not experiencing a drug or alcohol dependency, either a current or previous condition
    • not smoking more than five cigarettes per day
    • not using medication that affects neurological function (e.g., sedatives, antipsychotics)
    • not suffering from an uncorrected visual disorder
    • not diagnosed with a learning disability.

    For more information and to get started, visit www.borrowmybrain.org

  • Cognitive function in patients with different subtypes of Parkinson’s disease

    Volunteers are needed for a research project investigating Parkinson’s subtype and cognitive function in Parkinson’s disease. This project will examine how general cognitive function differs in two different subtypes of Parkinson’s disease: tremor-dominant and akinetic-rigid. It has been shown that these two subtypes of Parkinson’s disease are associated with different cognitive outcomes, yet the reasons for this are still unclear.

    This project will try to understand how patterns of cognitive performance differ between the two subtypes of Parkinson’s disease. In addition, we will investigate whether specific genetic information could be used to predict particular patterns of cognitive performance. Importantly, this understanding may improve our ability to predict who is at risk for the development of cognitive problems in people with Parkinson’s disease. Ultimately, this may lead to more personalised and effective treatment recommendations for cognitive dysfunction in Parkinson’s disease.

    What do participants have to do?

    • Attend two 2.5-3 hours sessions, in our city-based laboratory
      In the first session, individuals will be tested while taking their normal Parkinson’s medications. In the second session, individuals will be tested after 12-24 hours of not taking Parkinson’s medications.
    • Complete an online questionnaire before attending each session.
    • Complete a series of tests of general cognitive function (memory, vocabulary, attention).
    • Provide a saliva sample, which will be used for DNA testing in order to determine whether genotypes that influence neurological functioning are related to cognitive function.

    (All tests are non-invasive and should cause no discomfort).

    Eligibility requirements

    We are looking for participants who:

    • have a diagnosis of Parkinson’s disease
    • are fluent English speakers
    • have no previous diagnosis of dementia or a learning disability.

    Honorarium

    Participants will receive a $20 gift card after each of the two in-person sessions.

    Contact details for registrations of interest

    If you are interested and would like more information, please contact us:

    Email: cns_laboratory@adelaide.edu.au

    Phone: (08) 8313 0012