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Aquaporin Physiology and Drug Discovery Program

The dual water and ion channels known as aquaporins (AQPs) are found in all forms of life, from bacteria to vertebrates. They play key roles in water balance and fluid homeostasis across cell membranes. 

The Aquaporin Physiology and Drug Discovery laboratory aims to define the molecular basis of AQP function, understand the roles of AQPs in physiological systems, and build a definitive portfolio of AQP antagonist and agonist compounds as tools for basic research and clinical innovation.  

Our work over the past decade has challenged the assumptions about AQP function, leading to the existence of new knowledge of AQPs as ion channels, and as osmotic water channels. We have also defined the first library of pharmacological agents in the world and are now working with traditional Chinese and Indian medicinal herbs, as well as testing potentially powerful dual therapies for blocking cell migration.  

Our findings offer exciting translational opportunities for clinical intervention in cancer metastasis, brain oedema, hydrocephalus, and other fluid transport disorders. Our drug agents are currently being tested in collaborative projects in Australia, Europe and the United States of America.

Lead researcher: Professor Andrea Yool

Research team

Research support
Students 
  • Michael De Ieso (PhD candidate)
  • Pak Hin (Jeffrey) Chow (PhD candidate)
  • Saeed Nourmohammadi (PhD candidate)

Partnerships

  • Dr Sunita Ramesh
  • Professor David Adelson
  • Dr Caitlin Byrt
  • Professor Steve Tyerman

Interested in undertaking a postgraduate research degree with us?

We offer exciting opportunities for researchers at the honours, masters and PhD levels. Our research degrees are open to students from a broad range of backgrounds, and range from basic sciences to clinical research. If you are interested in human health, consider furthering your research career with us.

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