Stroke Research Program

The Stroke Research Program (SRP) engages with national research for stroke prevention, diagnosis and treatment.

Our stroke-related research investigates genetic and proteomic factors that may change the risk for stroke, inflammatory pathways involved in stroke and primary health stroke prevention. The SRP has been instrumental in helping establish dedicated stroke treatment units at major hospitals in Adelaide.

Research conducted by the SRP is helping to improve response times and health outcomes for individuals who have a stroke. We collaborate nationally and internationally in our stroke-related research on genetic and proteomic investigations. As part of this we investigate cellular and molecular therapeutic applications of adult stem cells to repair the brain after stroke. We also seek to elucidate genetic control factors for the Npas4 gene that affect the process of neurogenesis.

60,000 Australians suffer a stroke every year and one third are left with severe disability. One aspect of our research is to discover the best time after a stroke to intervene with molecular, cellular and/or rehabilitation therapies. At this stage it is uncertain as to when intervention is best administered to overcome stroke disability. We anticipate that there will be support through our research for an early adoption of multiple strategies including rehabilitation to enhance recovery following a stroke. Using research to better coordinate new therapies and providing rehabilitation at an optimum time will be an exciting advance in stroke recovery.

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  • Lead researcher

    Professor Simon Koblar

    Professor Simon Koblar

    Professor Koblar is a clinician scientist and stroke neurologist who established the Stroke Research Program (SRP) in 2005, now the major research program in stroke in South Australia. The SRP is a unique collaboration between the South Australian Health and Medical Research Institute, the University of Adelaide and the Central Adelaide Local Health Network (CALHN). Professor Koblar practices as a neurologist (public and private), and consults in stroke at the CALHN.

  • Research team

    Research team Role
    Associate Professor Anne Hamilton-Bruce Research staff
    Associate Professor Jim Jannes Research staff
    Associate Professor Tim Kleinig Research staff
    Dr Karlea Kremer Research staff
    Mr Austin Milton Research staff
    Dr Anupam Gupta, PhD candidate Research student
    Ms Maria Gancheva, PhD candidate Research student
    Ms Chelsea Graham, PhD candidate Research student
  • Partnerships

    • Professor Michael Greenberg, Professor of Neurobiology and Director, Department of Neurobiology, Harvard Medical School, Boston, MA, USA: Npas4 in neuronal development
    • Associate Professor Susan Hiller, University of South Australia: Acting fast to increase time-critical stroke treatments to all South Australians
    • Professor Chris Levi, Professor Hugh S. Markus and Dr Jane Maguire et al. via the Australian Stroke Genetics Collaborative: Stroke Genetics
    • Associate Professor Yingxi Lin, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA: Genetics of Neural Development and Brain Repair
    • Professor Stan Gronthos, Co-director, Centre for Stem Cell Research, University of Adelaide and Professor Andrew Zannettino, Myeloma Research Laboratory, University of Adelaide: Dental Pulp Stem Cells in Treatment of Stroke
    • Professor James Fawcett and Dr Jessica Kwok, Cambridge Centre for Brain Repair, University of Cambridge, UK: Neuroplasticity.
  • Related areas of research

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