Genome Editing Laboratory
CRISPR genome editing technology is transforming medicine, biology and agriculture. CRISPR enables targeted genetic modification of virtually any species with unprecedented efficiency. Since the first CRISPR editing publication in late 2012, more than 9000 papers have been published using this technology, highlighting the enormous impact of CRISPR in basic and applied research.
The Genome Editing Laboratory uses state-of-the-art molecular genetic approaches to develop CRISPR technology to enhance human health. We have generated more than 60 mouse models using CRISPR, many of which have been published in high profile international journals.
We are using CRISPR to understand the pathology of relatively common genetic diseases such as epilepsy and muscular dystrophy by generating CRISPR mice that model disease-causing mutations in humans. We are also developing approaches to cure genetic diseases by correcting disease-causing mutations in vivo.
Finally, we are leading the world in the development of CRISPR gene drives in mice. This powerful technology has enormous potential for controlling invasive mouse populations that spread (zoonotic) disease, cause species extinction and loss of agricultural productivity.
Professor Paul Thomas
Professor Paul Thomas leads the Genome Editing Laboratory and is Director of the SA Genome Editing (SAGE) Facility at the University of Adelaide and SAHMRI. He has over 20 years experience in generation and analysis of mouse models for neurodevelopmental diseases including intellectual disability and epilepsy. Professor Thomas has published >80 research articles and has considerable expertise in CRISPR/Cas genome editing through generation of >60 genetically modified mouse lines including first generation CRISPR gene drives.
Research team Role Professor Paul Thomas Lead researcher Stefka Tasheva Researcher - Post-Doctoral Fellow Fatwa Adikusuma Researcher - Post-Doctoral Fellow Alvaro Nieto Researcher - Post-Doctoral Fellow Sandra Piltz Research support - Research assistant Melissa White Research support - Research assistant Michaela Scherer Research support - Research assistant Ruby Dawson PhD student Chandran Pfitzner PhD student Ella Thomson PhD student Louise Robertson PhD student
Related areas of research
We offer exciting opportunities for researchers at the honours, masters and PhD levels. Our research degrees are open to students from a broad range of backgrounds, and range from basic sciences to clinical research. If you are interested in human health, consider furthering your research career with us.