Genome Editing Laboratory

CRISPR genome editing technology is transforming medicine, biology and agriculture. CRISPR enables targeted genetic modification of virtually any species with unprecedented efficiency. Since the first CRISPR editing publication in late 2012, more than 9000 papers have been published using this technology, highlighting the enormous impact of CRISPR in basic and applied research.

The Genome Editing Laboratory uses state-of-the-art molecular genetic approaches to develop CRISPR technology to enhance human health. We have generated more than 60 mouse models using CRISPR, many of which have been published in high profile international journals.

We are using CRISPR to understand the pathology of relatively common genetic diseases such as epilepsy and muscular dystrophy by generating CRISPR mice that model disease-causing mutations in humans. We are also developing approaches to cure genetic diseases by correcting disease-causing mutations in vivo.

Finally, we are leading the world in the development of CRISPR gene drives in mice. This powerful technology has enormous potential for controlling invasive mouse populations that spread (zoonotic) disease, cause species extinction and loss of agricultural productivity. 

  • Lead researcher

    Professor Paul Thomas

    Professor Paul Thomas leads the Genome Editing Laboratory and is Director of the SA Genome Editing (SAGE) Facility at the University of Adelaide and SAHMRI. He has over 20 years experience in generation and analysis of mouse models for neurodevelopmental diseases including intellectual disability and epilepsy. Professor Thomas has published >80 research articles and has considerable expertise in CRISPR/Cas genome editing through generation of >60 genetically modified mouse lines including first generation CRISPR gene drives.

  • Research team

    Research team Role
    Professor Paul Thomas Lead researcher
    Stefka Tasheva Researcher - Post-Doctoral Fellow
    Fatwa Adikusuma Researcher - Post-Doctoral Fellow
    Alvaro Nieto Researcher - Post-Doctoral Fellow
    Sandra Piltz Research support - Research assistant
    Melissa White Research support - Research assistant
    Michaela Scherer Research support - Research assistant
    Ruby Dawson PhD student
    Chandran Pfitzner PhD student
    Ella Thomson PhD student
    Louise Robertson PhD student
  • Related areas of research

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