We will undertake research to prevent deterioration in mobility as well as improve mobility. This research will help older people maintain independence and achieve healthy ageing.

  • Efficacy of botulinum toxin a in modifying spasticity to improve walking and quality of life in post-stroke lower limb spasticity - a randomised double-blind placebo controlled study

    Lead investigators: Associate Prof Anupam Datta Gupta

    This project is looking at how Botox injection into the tight (spastic) muscles following stroke can improve walking. This study involves participating in a 6 months trial with injection of Botox or placebo and assessment by the multidisciplinary rehabilitation team including Rehabilitation Medicine Specialist and Physiotherapist. Participants (18 years and above) will have one session of injection (either Botox or Placebo) after initial assessment and three subsequent follow up visits. All participants will have physiotherapy and walking training during the trial period.


    Gupta AD, Wilson DH. Botulinum toxin for spasticity: a case for change to the Pharmaceutical Benefits Scheme. MJA 208 (9) j 21 May 2018 doi: 10.5694/mja17.00841

    Gupta AD, Chu WH, Howell S, Chakraborty S, Koblar S, Visvanathan R, Cameron I, Wilson D. A systematic review: efficacy of botulinum toxin in walking and quality of life in post-stroke lower limb spasticity. Syst Rev. 2018 Jan 5;7(1):1. doi: 10.1186/s13643-017-0670-9. Review.

    Gupta AD,  Tucker G, Koblar S, Visvanathan R, Cameron ID. Spatiotemporal Gait Analysis and Lower Limb Functioning in Foot Dystonia Treated with Botulinum Toxin. Toxins 2018, 10, 532; doi:10.3390/toxins10120532

    Gupta AD, Visvanathan R. Botulinum toxin for foot dystonia in patients with Parkinson's disease having deep brain stimulation: A case series and a pilot study. J Rehabil Med. 2016 Jun 13;48(6):559-62. doi: 10.2340/16501977-2094.

    Media contact: Associate Professor Anupam Data Gupta