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Associate Professor Alex Swarbrick presented at the Adelaide Medical School Distinguished Speaker Series 2022
Associate Professor Alex Swarbrick, Senior Principal Research Fellow and co-leader of the Strategic program in Dynamic Cancer Ecosystems, Garvan Institute of Medical Research, Sydney presented a seminar entitled "Solid tumours as cellular ecosystems: new insights into disease stratification and treatment", on 7 April, 2022, in the AHMS Building, University of Adelaide. The seminar covered how new technologies, including single cell sequencing and high-dimensionality tissue analysis, are enabling new insights into cancer ecosystems, leading to advances in the stratification and treatment of solid cancers. A/Prof Swarbrick is a developmental biologist with a long-standing interest in how cells in developing embryos control the decision to divide or to differentiate in co-ordination with cell cycle events, as well as how this co-ordination is subverted in cancers. The seminar was hosted by Prof Wayne Tilley, DRMCRL Director.
Prof Tilley contributes to the US Prostate Cancer Foundation Retreat: State of Science Report.
Research from Prof Tilley’s laboratory on “Nuclear receptor biology in castration resistant prostate cancer” was presented at the 28th Annual Prostate Cancer Foundation (PCF) Scientific Retreat, Carlsbad, USA in November, 2021. In a session that focused on nuclear receptor biology, including the role of GR in CRPC and its potential as a therapeutic target, as well as the impact of AR agonism in prostate cancer and ER-positive breast cancer, Prof Tilley presented data that suggested a role for potent AR agonists and that warranted further study into the potential for selective AR modulators in the treatment of breast and prostate cancer. His paper formed part of the PCF’s State of Science Report. In addition, the PCF Retreat Scientific Meeting Report will be published in the scientific journal, The Prostate.
DRMCRL Visiting Professor Iggo publishes on breast cancer organoid and intraductal models
Professor Richard Iggo, Professor of Cell Biology, University of Bordeaux / Visiting Professor, University of Adelaide has published the methodology, currently utilised at the DRMCRL, for creating breast cancer models by transducing tumor cells and normal mammary epithelial cells with lentiviral vectors in organoid culture and injecting them into the mammary ducts of mice. This article entitled "Modeling breast cancer in organoid and intraductal models" was published in Mammary Stem Cells, a Methods in Molecular Biology book series, and describes the protocols to create estrogen receptor positive (ER+) and androgen receptor positive (AR+) breast cancer models by combining organoid culture with mammary intraductal injection. doi: 10.1007/978-1-0716-2193-6_13
DRMCRL celebrates International Women’s Day 2022
The ladies of the DRMCRL came together to celebrate 2022 International Women’s Day on March 8, and this year we welcomed newcomers Dr Katherine Morel, postdoctoral researcher and Maliha Wajahat, PhD student. Also joining us on the day was Allegra Freelander, a visiting researcher from our collaborator’s lab (Prof Elgene Lim) at the Garvan Institute for Medical Research, Sydney. It was a beautiful day to enjoy the stunning Adelaide Botanic Garden and the tours run by the University of Adelaide External Relations team as part of the International Women’s Day 2002 event. https://twitter.com/drmcrl/status/1501132807841927169
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