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2022 Florey Postgraduate Research Conference prize recipient
The Florey Postgraduate Research Conference, held on 21 September at the Adelaide Convention Centre, was a highlight for the Faculty of Health and Medical Sciences Faculty showcasing outstanding research activity. DRMCRL PhD student Wenjun (Nora) Liu was awarded the Florey Medical Research Foundation (Applied) prize for achieving the highest score in the applied science field for her poster presentation “Make sense of noisy patient-derived data: A novel workflow for deconvoluting bulk RNA-seq data to unveil transcriptional responses to androgen in breast tissues". Well done Nora! The conference, now in its 16th year, gives HDR students the opportunity to discuss their research with fellow students, academics, industry partners, and other major stakeholders of the University. It is a chance to recognise excellent in research, hear from distinguished speakers on specialised topics, and beneficial to HDR students for ongoing professional and personal development. 2022 Florey Postgraduate Conference prize list here. See Nora on Twitter here.
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Cancer Australia funding for arming androgen receptors to transform endocrine therapy for ER+ breast cancer
Associate Professor Theresa Hickey and her team have received $600,000 from Cancer Australia to support research to examine the complex interaction between estrogen and androgen to develop new, more effective strategies for treating breast cancer, with potential to also improve quality of life.
Latest news in breast cancer trials meeting
Breast Cancer Trials (BCT) held their 43rd Annual Scientific Meeting in Melbourne on July 27-30.
In the Translational Research session at this meeting, Prof Wayne Tilley, Director of the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) presented work on "Understanding the role of the androgen receptor" as targeting the androgen receptor (AR) in breast cancer has been of intense clinical interest over the past two decades.
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DRMCRL Team – MDC winners four consecutive years running!
DRMCRL lab members participated in the NBCF 2022 Mothers Day Classic (MDC) with a 5km River Torrens circuit, and for the fourth straight year have won the trophy for the Largest Higher Education Team in South Australia.
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DRMCRL research presented at the 3rd Nuclear Receptors Conference, 4 -7 May 2022
DRMCRL Director, Prof Wayne Tilley and Prof Charlotte Bevan (Imperial College London) co-chaired the 3rd Nuclear Receptor meeting, which returned to a face to face format in Cancun, Mexico, after being postponed for the last two years.
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Associate Professor Alex Swarbrick presented at the Adelaide Medical School Distinguished Speaker Series 2022
Associate Professor Alex Swarbrick, Senior Principal Research Fellow and co-leader of the Strategic program in Dynamic Cancer Ecosystems, Garvan Institute of Medical Research, Sydney presented a seminar entitled "Solid tumours as cellular ecosystems: new insights into disease stratification and treatment", on 7 April, 2022, in the AHMS Building, University of Adelaide. The seminar covered how new technologies, including single cell sequencing and high-dimensionality tissue analysis, are enabling new insights into cancer ecosystems, leading to advances in the stratification and treatment of solid cancers. A/Prof Swarbrick is a developmental biologist with a long-standing interest in how cells in developing embryos control the decision to divide or to differentiate in co-ordination with cell cycle events, as well as how this co-ordination is subverted in cancers. The seminar was hosted by Prof Wayne Tilley, DRMCRL Director.
Prof Tilley contributes to the US Prostate Cancer Foundation Retreat: State of Science Report.
Research from Prof Tilley’s laboratory on “Nuclear receptor biology in castration resistant prostate cancer” was presented at the 28th Annual Prostate Cancer Foundation (PCF) Scientific Retreat, Carlsbad, USA in November, 2021. In a session that focused on nuclear receptor biology, including the role of GR in CRPC and its potential as a therapeutic target, as well as the impact of AR agonism in prostate cancer and ER-positive breast cancer, Prof Tilley presented data that suggested a role for potent AR agonists and that warranted further study into the potential for selective AR modulators in the treatment of breast and prostate cancer. His paper formed part of the PCF’s State of Science Report. In addition, the PCF Retreat Scientific Meeting Report will be published in the scientific journal, The Prostate.
DRMCRL Visiting Professor Iggo publishes on breast cancer organoid and intraductal models
Professor Richard Iggo, Professor of Cell Biology, University of Bordeaux / Visiting Professor, University of Adelaide has published the methodology, currently utilised at the DRMCRL, for creating breast cancer models by transducing tumor cells and normal mammary epithelial cells with lentiviral vectors in organoid culture and injecting them into the mammary ducts of mice. This article entitled "Modeling breast cancer in organoid and intraductal models" was published in Mammary Stem Cells, a Methods in Molecular Biology book series, and describes the protocols to create estrogen receptor positive (ER+) and androgen receptor positive (AR+) breast cancer models by combining organoid culture with mammary intraductal injection. doi: 10.1007/978-1-0716-2193-6_13
DRMCRL celebrates International Women’s Day 2022
The ladies of the DRMCRL came together to celebrate 2022 International Women’s Day on March 8, and this year we welcomed newcomers Dr Katherine Morel, postdoctoral researcher and Maliha Wajahat, PhD student. Also joining us on the day was Allegra Freelander, a visiting researcher from our collaborator’s lab (Prof Elgene Lim) at the Garvan Institute for Medical Research, Sydney. It was a beautiful day to enjoy the stunning Adelaide Botanic Garden and the tours run by the University of Adelaide External Relations team as part of the International Women’s Day 2002 event. https://twitter.com/drmcrl/status/1501132807841927169
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DRMCRL researchers attend 34th Annual Lorne Cancer Conference 2022
Professor Wayne Tilley, Associate Professor Theresa Hickey and Dr Amy Dwyer attended the 2022 Annual Lorne Cancer Conference (https://www.lornecancer.org/) held at the Mantra Lorne. Assoc Prof Hickey gave a first session talk on "The androgen receptor as a therapeutic target in breast cancer", and Amy gave a Flash Talk on "High throughput cell morphology-based drug-screens in breast and prostate cancer reveals novel AR agonists". Both presentations were very well received.
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