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Associate Professor Theresa Hickey publishes paper in Nature Medicine on a suppression role for AR in breast cancer
Androgen receptor (AR)-directed therapies are controversial in (ER)-α-positive breast cancer treatment. Associate Professor Hickey et al have published a paper entitled “The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer” that demonstrates AR activation, not suppression, exerts potent anti-tumor activity in multiple disease contexts, including resistance to standard-of-care ER and CDK4/6 inhibitors. Notably, AR agonists combined with standard-of-care agents enhanced therapeutic responses. These findings provide unambiguous evidence that AR has a tumor suppressor role in ER-positive breast cancer and support AR agonism as the optimal AR-directed treatment strategy, revealing a rational therapeutic opportunity.
Dr Amy Dwyer publishes paper in the British Journal of Cancer on a role for IGF/insulin in breast cancer
Dr Amy Dwyer was first author on a paper recently published in BJC entitled "Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor–driven stemness and endocrine resistance in oestrogen receptor+ breast cancer". Amy’s work for this paper was undertaken during her postdoctoral appointment at The Masonic Cancer Center, University of Minnesota, Minneapolis, USA. Well done Amy!
DRMCRL students Danielle Fang and Ebithal Mustafa awarded prizes
PhD student Danielle Fang was awarded an Innovation and Commercial Partners Prize at the 2020 Virtual Florey Postgraduate Research Conference in October, 2020. Her poster was entitled "USP2: A key driver in lethal prostate cancer?" In November 2020, PhD student Ebithal Mustafa was awarded the Australian Women in Endocrinology Prize at the 63rd ESA Annual Scientific meeting (virtual). Her poster entitled "TFAP-2β interacts with AR to determine the phenotype and growth of molecular apocrine breast cancer" was the highest ranked science poster in the e-poster award finalist group. Congratulations to Danielle and Ebi!
[Read more about DRMCRL students Danielle Fang and Ebithal Mustafa awarded prizes ]
Symposium: Patient-derived in vitro models - Advances and challenges
Dr Jean Winter gave a presentation on "Advances and challenges of high-throughput 3D imaging using patient derived samples" as related to her breast cancer research, at the symposium organised by the South Australian Cancer Research Institute / University of South Australia. This focused symposium attracted more than 110 participants from 17 universities and research institutes across the country. Models and enabling technologies featured in the program were prostate cancer explants, and organoids derived from liver, nasal cells, ovary, breast and bowel cancer.
[Read more about Symposium: Patient-derived in vitro models - Advances and challenges]
Mother’s Day Classic Adelaide, 2020
It's great to see that nothing can stop us from having our walk/run for @MDC_walk_run 2020! Thanks everyone for virtually participating to support breast cancer research and awareness in the Women in Super Mother's Day Classic annual event! Together we are strong!
https://twitter.com/drmcrl/status/1259382293166059521
Movember- National Breast Cancer Foundation Collaborative Linkage Program engagement meeting held in Sydney
Our Collaborative Linkage grant team members met in Sydney on 10 March 2020 to showcase and discuss the progress on our research program in "Transforming endocrine therapy for breast and prostate cancer". Representatives from each of the project’s node at the University of Adelaide, Monash University and the Garvan Institute attended in person or via teleconference, as did our funding sponsors, Movember and NBCF, and some of our consumer advocates.
Professor Wayne Tilley co-convenes the 2nd Nuclear Receptors Conference
Nuclear receptors are critical determinants of everyday health. They drive key processes at every stage from development and reproduction to ageing and cancer. Professor Tilley was Co-Convenor and Chairperson at this year’s meeting which had the theme of "New Roles for Nuclear Receptors in Development, Health and Disease". The 2020 meeting brought together many of the leading experts in nuclear receptor research from across the globe to generate meaningful idea exchanges and interactions that will help to further shape this influential field.
[Read more about Professor Wayne Tilley co-convenes the 2nd Nuclear Receptors Conference]
Rayzel Fernandes - PhD conferral
Congratulations to Rayzel Fernandes on the conferral of her doctoral degree entitled “The role of microRNA-194 in prostate cancer progression”. Rayzel’s project was supported by an International Postgraduate Research Scholarship/ Australian Postgraduate Award, as well as a Freemason’s Foundation Centre for Men’s Health PhD Scholarship top-up award. Rayzel will be leaving the DRMCRL to take up a post-doctoral position at Imperial College London.
Professor Wayne Tilley co-convenes the 15th Indo-Australian Biotechnology Conference in Adelaide
The 15th Indo-Australian Biotechnology Conference, held biennially in Australia, was hosted by the DRMCRL on 16-18 November in Adelaide.
NHMRC 2020 Ideas Grant success for DRMCRL
The DRMCRL is excited to announce we have been awarded an NHMRC Ideas Grant for funding commencing in 2020. Professor Wayne Tilley will be the PI for the project entitled “A combinatorial drug strategy to target lethal forms of breast cancer” which will address a critical unmet need by combining new treatment strategies in the most lethal forms of breast cancer.
