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DRMCRL Visiting Professor Iggo publishes on breast cancer organoid and intraductal models
Professor Richard Iggo, Professor of Cell Biology, University of Bordeaux / Visiting Professor, University of Adelaide has published the methodology, currently utilised at the DRMCRL, for creating breast cancer models by transducing tumor cells and normal mammary epithelial cells with lentiviral vectors in organoid culture and injecting them into the mammary ducts of mice. This article entitled "Modeling breast cancer in organoid and intraductal models" was published in Mammary Stem Cells, a Methods in Molecular Biology book series, and describes the protocols to create estrogen receptor positive (ER+) and androgen receptor positive (AR+) breast cancer models by combining organoid culture with mammary intraductal injection. doi: 10.1007/978-1-0716-2193-6_13
DRMCRL celebrates International Women’s Day 2022
The ladies of the DRMCRL came together to celebrate 2022 International Women’s Day on March 8, and this year we welcomed newcomers Dr Katherine Morel, postdoctoral researcher and Maliha Wajahat, PhD student. Also joining us on the day was Allegra Freelander, a visiting researcher from our collaborator’s lab (Prof Elgene Lim) at the Garvan Institute for Medical Research, Sydney. It was a beautiful day to enjoy the stunning Adelaide Botanic Garden and the tours run by the University of Adelaide External Relations team as part of the International Women’s Day 2002 event. https://twitter.com/drmcrl/status/1501132807841927169
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DRMCRL researchers attend 34th Annual Lorne Cancer Conference 2022
Professor Wayne Tilley, Associate Professor Theresa Hickey and Dr Amy Dwyer attended the 2022 Annual Lorne Cancer Conference (https://www.lornecancer.org/) held at the Mantra Lorne. Assoc Prof Hickey gave a first session talk on "The androgen receptor as a therapeutic target in breast cancer", and Amy gave a Flash Talk on "High throughput cell morphology-based drug-screens in breast and prostate cancer reveals novel AR agonists". Both presentations were very well received.
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Congratulations Amy Dwyer, recipient of a 2022 NBCF Fellowship!
DRMCRL postdoctoral scientist, Dr Amy Dwyer has been awarded a 2022 National Breast Cancer Foundation Investigator Initiated Research Scheme (NBCF IIRS) Fellowship. This four year Fellowship enables Amy to undertake her research on "Reprogramming the estrogen receptor to eradicate endocrine-resistant breast cancer". Well done Amy!
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Wenjun Liu awarded scholarship for BioInfoSummer 2021
DRMCRL PhD student Wenjun Liu was awarded a scholarship by the Australian Mathematical Science Institute (AMSI) to attend and present at BioInfoSummer 2021. This four-day (29 Nov – 2 Dec 2021) hybrid symposium was held across event hubs at The University of Adelaide, The University of Melbourne, Curtin University, James Cook University and UNSW. Participants explored bioinformatics under the themes: High Performance Computing for Bioinformatics; Computational Methods in Human Genomic Health; Metagenomics and Long Reads. Wenjun presented her ePoster entitled "RNA-seq regulatory network inference revealed an association between transcription factor SETX and neurogenerative pathways under prolonged autophagy induction" at the conference, which can be found here: https://bis.amsi.org.au/eposters/
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Congratulations! Leila Hosseinzadeh – Dean's commendation for doctoral research excellence
Another DRMCRL student has been awarded a Higher Degree by Research. Leila Hosseinzadeh’s PhD thesis entitled: “Role of the GATA3 transcription factor in mediating androgen receptor signalling in breast cancer” has academically qualified her for the degree of Doctor of Philosophy and a Deans Commendation for Research Excellence. Leila is on a hat trick - with preparation of a manuscript from her thesis work, and an offer of a post-doctoral position in Canada with Dr Mathieu Lupien. Great job Leila!
MDC2021: Mother’s Day Classic Winners again!
Congratulations to the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) who participated in the 2021 NBCF Mother’s Day Classic. For the third year in a row, the DRMCRL team won the trophy for the Largest Higher Education Team in South Australia (sponsored by UniSuper). Well done to our team; Theresa, Eva and Jack, Amy, Richard, Alex, Wayne, Stephen, Elizabeth, Geri, Nora and Zoya; who walked/ran 8 km to support life-saving breast cancer research and awareness.
https://twitter.com/drmcrl/status/1391252049505832963
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Inaugural ”AHMS on Steroids” event
The DRMCRL kick-started a multidisciplinary social interest group of researchers who share the passion and knowledge for steroids/steroid hormone receptors. The “AHMS on Steroids” events aim to create an informal, fun environment for engaging discussions, networking, and collaborative opportunities. As inaugural host, DRMCRL Director Prof Wayne Tilley, welcomed about 30 people from across the AHMS building, Molecular Biosciences, SAHMRI, University of South Australia and Basil Hetzel Institute. We hope this will be the first of many stimulating and rewarding events.
Associate Professor Hickey guest speaker at the Ovarian Cancer Australia Morning Teal Event in Adelaide today
Associate Professor Theresa Hickey was the guest researcher speaking at the Ovarian Cancer Australia Morning Teal event hosted today by Senator Simon Birmingham (Federal Finance Minister) at the Adelaide Health and Medical Sciences building, University of Adelaide. Theresa’s presentation (I’m OVARY-ACTING for a Breakthrough: Insights from breast cancer) highlighted activating the androgen receptor (AR) with “male” hormones as a new therapeutic approach in breast cancer recently published in Nature Medicine. Theresa discussed how this research has implications for ovarian cancer. Associate Professor Hickey was able to meet and discuss her seminal work on androgens in breast cancer with Senator Birmingham, Professor Peter Hoj (Vice Chancellor, University of Adelaide), Abbie Taylor (Ambassador, Ovarian Cancer Australia), John Gardner MP (Minister for Education, SA) and the many others, including students, present at the function.
Excellent cartoon video explaining the DRMCRL breast cancer advance story
Watch this short video explaining the AR breast cancer story published recently in Nature Medicine (Hickey et al, Vol 27, 310-320; http://dx.doi.org/10.1038/s41591-020-01168-7).
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