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Associate Professor Theresa Hickey publishes paper in Nature Medicine on a suppression role for AR in breast cancer
Androgen receptor (AR)-directed therapies are controversial in (ER)-α-positive breast cancer treatment. Associate Professor Hickey et al have published a paper entitled “The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer” that demonstrates AR activation, not suppression, exerts potent anti-tumor activity in multiple disease contexts, including resistance to standard-of-care ER and CDK4/6 inhibitors. Notably, AR agonists combined with standard-of-care agents enhanced therapeutic responses. These findings provide unambiguous evidence that AR has a tumor suppressor role in ER-positive breast cancer and support AR agonism as the optimal AR-directed treatment strategy, revealing a rational therapeutic opportunity.
PRESS RELEASE! New discovery in breast cancer treatment by researchers at the University of Adelaide and the Garvan Institute for Medical Research
Associate Professor Theresa Hickey, Professor Wayne Tilley (University of Adelaide) and Associate Professor Elgene Lim (Garvan Institute) have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Read the Press Release and watch a video on how androgen receptor activation can suppress tumour activity.
