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Congratulations to Theresa Hickey - 2020 Executive Dean’s Research Award recipient
Associate Professor Theresa Hickey has been awarded the 2020 Executive Dean’s Research Award in the mid-career researcher (MCR) category. Her excellence was recognised in the areas of publication of outstanding research in high ranking, peer reviewed journals; significant contribution to successful grant applications; development and implementation of a multidisciplinary research project; significant contribution to the public awareness of health and medical science; successful commercialisation of a research idea and scholarly activities that have had, or are likely to have, a major impact on the health outcomes of individuals and/or populations.
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PRESS RELEASE! New discovery in breast cancer treatment by researchers at the University of Adelaide and the Garvan Institute for Medical Research
Associate Professor Theresa Hickey, Professor Wayne Tilley (University of Adelaide) and Associate Professor Elgene Lim (Garvan Institute) have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Read the Press Release and watch a video on how androgen receptor activation can suppress tumour activity.
Associate Professor Theresa Hickey publishes paper in Nature Medicine on a suppression role for AR in breast cancer
Androgen receptor (AR)-directed therapies are controversial in (ER)-α-positive breast cancer treatment. Associate Professor Hickey et al have published a paper entitled “The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer” that demonstrates AR activation, not suppression, exerts potent anti-tumor activity in multiple disease contexts, including resistance to standard-of-care ER and CDK4/6 inhibitors. Notably, AR agonists combined with standard-of-care agents enhanced therapeutic responses. These findings provide unambiguous evidence that AR has a tumor suppressor role in ER-positive breast cancer and support AR agonism as the optimal AR-directed treatment strategy, revealing a rational therapeutic opportunity.
Dr Amy Dwyer publishes paper in the British Journal of Cancer on a role for IGF/insulin in breast cancer
Dr Amy Dwyer was first author on a paper recently published in BJC entitled "Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor–driven stemness and endocrine resistance in oestrogen receptor+ breast cancer". Amy’s work for this paper was undertaken during her postdoctoral appointment at The Masonic Cancer Center, University of Minnesota, Minneapolis, USA. Well done Amy!
DRMCRL students Danielle Fang and Ebithal Mustafa awarded prizes
PhD student Danielle Fang was awarded an Innovation and Commercial Partners Prize at the 2020 Virtual Florey Postgraduate Research Conference in October, 2020. Her poster was entitled "USP2: A key driver in lethal prostate cancer?" In November 2020, PhD student Ebithal Mustafa was awarded the Australian Women in Endocrinology Prize at the 63rd ESA Annual Scientific meeting (virtual). Her poster entitled "TFAP-2β interacts with AR to determine the phenotype and growth of molecular apocrine breast cancer" was the highest ranked science poster in the e-poster award finalist group. Congratulations to Danielle and Ebi!
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Symposium: Patient-derived in vitro models - Advances and challenges
Dr Jean Winter gave a presentation on "Advances and challenges of high-throughput 3D imaging using patient derived samples" as related to her breast cancer research, at the symposium organised by the South Australian Cancer Research Institute / University of South Australia. This focused symposium attracted more than 110 participants from 17 universities and research institutes across the country. Models and enabling technologies featured in the program were prostate cancer explants, and organoids derived from liver, nasal cells, ovary, breast and bowel cancer.
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Mother’s Day Classic Adelaide, 2020
It's great to see that nothing can stop us from having our walk/run for @MDC_walk_run 2020! Thanks everyone for virtually participating to support breast cancer research and awareness in the Women in Super Mother's Day Classic annual event! Together we are strong!
https://twitter.com/drmcrl/status/1259382293166059521
Movember- National Breast Cancer Foundation Collaborative Linkage Program engagement meeting held in Sydney
Our Collaborative Linkage grant team members met in Sydney on 10 March 2020 to showcase and discuss the progress on our research program in "Transforming endocrine therapy for breast and prostate cancer". Representatives from each of the project’s node at the University of Adelaide, Monash University and the Garvan Institute attended in person or via teleconference, as did our funding sponsors, Movember and NBCF, and some of our consumer advocates.
Mother’s Day Classic – National Breast Cancer Foundation’s (NBCF) annual fund raiser
Every single day, 50 women are diagnosed with breast cancer in Australia. University of Adelaide researchers at the DRMCRL work on research programs to improve disease outcomes by deeply understanding the role of sex hormones in tumour behaviour. Their research will be used to develop new drugs and treatments.
Dr Luke Selth – inaugural Rob Sutherland Award recipient
Dr Luke Selth from the DRMCRL was the inaugural Rob Sutherland Award recipient at\ this year’s PacRim meeting. This award, presented to an outstanding early/mid-career researcher, was the awarded by Rob Sutherland’s daughter and wife, Sarah and Cheryl Sutherland, at the PacRim Meeting Big Bash conference dinner at Seppeltsfield on last evening of the meeting.
[Read more about Dr Luke Selth – inaugural Rob Sutherland Award recipient ]