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MDC2021: Mother’s Day Classic Winners again!
Congratulations to the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) who participated in the 2021 NBCF Mother’s Day Classic. For the third year in a row, the DRMCRL team won the trophy for the Largest Higher Education Team in South Australia (sponsored by UniSuper). Well done to our team; Theresa, Eva and Jack, Amy, Richard, Alex, Wayne, Stephen, Elizabeth, Geri, Nora and Zoya; who walked/ran 8 km to support life-saving breast cancer research and awareness.
https://twitter.com/drmcrl/status/1391252049505832963
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Dean’s commendation for doctoral thesis excellence - Congratulations Raj!
Raj Kumar Shrestha’s PhD thesis work entitled: “Elucidating the molecular mechanisms underlying androgen-regulated lipid metabolism in prostate cancer” has been conferred with a Commendation for Doctoral Research Excellence by the Dean of Graduate Studies. Well done Raj! Raj’s PhD work was supported by an Adelaide Scholarship International (ASI), and a Freemasons Centre for Male Health and Wellbeing top-up scholarship.
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Inaugural ”AHMS on Steroids” event
The DRMCRL kick-started a multidisciplinary social interest group of researchers who share the passion and knowledge for steroids/steroid hormone receptors. The “AHMS on Steroids” events aim to create an informal, fun environment for engaging discussions, networking, and collaborative opportunities. As inaugural host, DRMCRL Director Prof Wayne Tilley, welcomed about 30 people from across the AHMS building, Molecular Biosciences, SAHMRI, University of South Australia and Basil Hetzel Institute. We hope this will be the first of many stimulating and rewarding events.
Associate Professor Hickey guest speaker at the Ovarian Cancer Australia Morning Teal Event in Adelaide today
Associate Professor Theresa Hickey was the guest researcher speaking at the Ovarian Cancer Australia Morning Teal event hosted today by Senator Simon Birmingham (Federal Finance Minister) at the Adelaide Health and Medical Sciences building, University of Adelaide. Theresa’s presentation (I’m OVARY-ACTING for a Breakthrough: Insights from breast cancer) highlighted activating the androgen receptor (AR) with “male” hormones as a new therapeutic approach in breast cancer recently published in Nature Medicine. Theresa discussed how this research has implications for ovarian cancer. Associate Professor Hickey was able to meet and discuss her seminal work on androgens in breast cancer with Senator Birmingham, Professor Peter Hoj (Vice Chancellor, University of Adelaide), Abbie Taylor (Ambassador, Ovarian Cancer Australia), John Gardner MP (Minister for Education, SA) and the many others, including students, present at the function.
DRMCRL researchers attend 33rd Annual Lorne Cancer Conference 2021
Professor Wayne Tilley, Associate Professor Theresa Hickey and Dr Amy Dwyer attended the 2021 Annual Lorne Cancer Conference held at the Mantra Lorne. The Lorne Cancer Conference was a unique experience with Victoria entering into a 5-day lockdown from Friday 12th February. This resulted in the program for Saturday being restructured to accommodate the postponed sessions from Friday.
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Excellent cartoon video explaining the DRMCRL breast cancer advance story
Watch this short video explaining the AR breast cancer story published recently in Nature Medicine (Hickey et al, Vol 27, 310-320; http://dx.doi.org/10.1038/s41591-020-01168-7).
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Congratulations to Theresa Hickey - 2020 Executive Dean’s Research Award recipient
Associate Professor Theresa Hickey has been awarded the 2020 Executive Dean’s Research Award in the mid-career researcher (MCR) category. Her excellence was recognised in the areas of publication of outstanding research in high ranking, peer reviewed journals; significant contribution to successful grant applications; development and implementation of a multidisciplinary research project; significant contribution to the public awareness of health and medical science; successful commercialisation of a research idea and scholarly activities that have had, or are likely to have, a major impact on the health outcomes of individuals and/or populations.
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PRESS RELEASE! New discovery in breast cancer treatment by researchers at the University of Adelaide and the Garvan Institute for Medical Research
Associate Professor Theresa Hickey, Professor Wayne Tilley (University of Adelaide) and Associate Professor Elgene Lim (Garvan Institute) have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Read the Press Release and watch a video on how androgen receptor activation can suppress tumour activity.
Associate Professor Theresa Hickey publishes paper in Nature Medicine on a suppression role for AR in breast cancer
Androgen receptor (AR)-directed therapies are controversial in (ER)-α-positive breast cancer treatment. Associate Professor Hickey et al have published a paper entitled “The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer” that demonstrates AR activation, not suppression, exerts potent anti-tumor activity in multiple disease contexts, including resistance to standard-of-care ER and CDK4/6 inhibitors. Notably, AR agonists combined with standard-of-care agents enhanced therapeutic responses. These findings provide unambiguous evidence that AR has a tumor suppressor role in ER-positive breast cancer and support AR agonism as the optimal AR-directed treatment strategy, revealing a rational therapeutic opportunity.
Dr Amy Dwyer publishes paper in the British Journal of Cancer on a role for IGF/insulin in breast cancer
Dr Amy Dwyer was first author on a paper recently published in BJC entitled "Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor–driven stemness and endocrine resistance in oestrogen receptor+ breast cancer". Amy’s work for this paper was undertaken during her postdoctoral appointment at The Masonic Cancer Center, University of Minnesota, Minneapolis, USA. Well done Amy!
