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Fracture and Frailty

Fragility fractures are common in frail older people. Better post-operative care is likely to translate into greater independence.

  • Perioperative anaemia, frailty and outcomes in hip fractures in older people

    Lead Investigators: Dr Kareeann Khow PhD Candidate, Professor Renuka Visvanathan, Assoc Prof Mellick Chehade, Dr Olga Theou and Dr Pazhvoor Shibu

    Old lady pouring tea Hip fractures in older people are costly to healthcare system because of adverse outcomes. These fractures are commonly associated with significant blood loss, either from the fracture itself or postoperatively, resulting in anaemia. Anaemia may develop at different time points of a hip fracture with potentially differing effects on clinical outcomes such as postoperative functional recovery, length of hospital stay and readmission rates. Most studies examined the association of anaemia at various time points but no study has examined the impact of change in haemoglobin levels (i.e. discharge compared with pre-admission levels) on outcomes.

    Frailty is also another important risk factor for adverse clinical outcomes after hip fractures. A systematic review of studies on perioperative anaemia and clinical outcomes in hip fracture surgery is currently being undertaken. This will be followed by an observational study on older people with hip fractures treated surgically to examine the relationship between peri-operative haemoglobin levels, frailty and clinical outcomes. This research will provide vital data on future interventional studies to manage perioperative anaemia and frailty with hip fractures.

    Media Contact: Dr Kareeann Khow

Centre of Research Excellence in
Frailty and Healthy Ageing



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