| Surgical considerations have focused on inflammatory bowel
disease (Crohn's Diesease and Ulcerative Colitis) as well as colon and
rectal cancer. Abdominal laparoscopic surgery has been explored with regard to newer techniques.
Regarding Crohn's disease surgery is based on conservative methods using,
where possible, detection of mucosal organisms, particularly mycoplasma
as a guide. Operations for rectal cancer include development of a "restorative
proctectomy" and a posterier rectal approach may permit new potential for
improving continence procedures.
Surgery has also focused on staging of pilonidal sinuses with ultra
sound-mapping providing an optimal surgical approach with improved healing.
Current Research
1. Detection of Mycoplasma species by PCR in inflammatory bowel disease.
2. Evaluation of NO (nitric oxide) in the causation of ulcerative
colitis through nitrosothiol formation in the colonic mucosa.
3. Ultrasound staging of pilonidal disease to assist surgical
management.
4. The use of colo-anal anastomoses in surgical management of rectal
cancer.
PUBLICATIONS
Roediger WEW, Gibbons GF. Inflammatory demyelination could be attributed to nitric oxide inhibition of cytosolic CoA with failed lipogenesis. Journal of Neurology, 2005; 252: 1418-1419.
Roediger WE, Hems R, Wiggins R, Gibbons GF. Inhibition of hepatocyte lipogenesis by nitric oxide donor: Could nitric oxide regulate lipid synthesis? IUBMB Life 2004; 56(1) 35-40.
Roediger WEW. Intestinal mycoplasma in Crohn's disease. In Jewell D, ed. Inflammatory Bowel Disease: Crossroads of microbes, epithelium and immune systems. Chichester: Wiley, 2004; pp. 85-98.
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