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Dr Paul Drew
PhD
Visiting Research Fellow
Contact details
Discipline of Surgery
Level 5, Eleanor Harrald Building
Royal Adelaide Hospital
Ph: +61 8 8222 4143
Fax: +61 8 8222 5896
Email: paul.drew@adelaide.edu.au
Biography
• PhD, Department of Microbiology and Immunology, The University of Adelaide
• Research Scientist in the Department of Surgery
• Senior Lecturer, School of Nursing and Midwifery Flinders University
The current research investigates how genes are regulated in cancer, particularly by DNA methylation or microRNAs. Changes that can be detected easily in patient specimens, and which would be useful diagnostic or prognostic biomarkers; that is, might indicate that a patient with early change in their tissues is at high risk of developing cancer, or that cancer is present, or that metastasis of a cancer is likely; or that might guide the tailoring of specific therapies or predict survival, are investigated. This research is applied to understanding gastro-oesophageal reflux disease and oesophageal cancer.
Research interests
• DNA methylation
• MicroRNAs
• Oesophageal cancer
• Barrett’s oesophagus
• Gastrointestinal diseases
Recent publications
• Smith E, Jones ME, Drew PA. Quantitation of DNA methylation by melt curve analysis. BMC Cancer 2009; 9: 123.
• Liu JF, Zhu GJ, Jamieson GG, Wu TC, Zhu TN, Shan BE, Drew PA. NS-398 induces apoptosis in human oesophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2. Cancer Invest 2009; 27(1): 17-23.
• Liu JF, Jamieson GG, Wu TC, Zhu GJ, Drew PA. A preliminary study on the post-operative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia. Ann Surg Oncol 2009; 16: 13971402.
• Tsunoda S, Smith E, De Young NJ, Wang X, Tian ZQ, Liu JF, Jamieson GG, Drew PA. Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma. Oncol Rep 2009; 21: 1067–73.
• Smith E, De Young NJ, Tian ZQ, Caruso M, Ruszkiewicz AR, Liu JF, Jamieson GG, Drew PA. Methylation of TIMP3 in esophageal squamous cell carcinoma. World J Gastroenterol 2008; 14(2): 203-210.
• Liu JF, Zhang SW, Jamieson GG, Zhu GJ, Wu TC, Zhu TN, Shan BE, Drew PA. The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo. Int J Cancer 2008; 122(7): 1639-1644.
• Kendall BJ, Macdonald GA, Hayward NK, Prins JB, Brown I, Walker N, Pandeya N, Green AC, Webb PM, Whiteman DC, for the Study of Digestive Health: Smith KJ, O'Brien SM, Smithers MB, Gotley DC, Webb PM, Green AC, Whiteman DC, Hayward NK, Parsons PG, Pavey SJ, Purdie DM, Jamieson GG, Drew PA, Watson DI, Clouston A. Leptin and the risk of Barrett’s oesophagus. Gut 2008; 57: 448-454.
• Nancarrow DJ, Handoko HY, Smithers BM, Gotley DC, Drew PA, Watson DI, Clouston AD, Hayward NK, Whiteman DC. Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays. Cancer Research 2008; 68: 4163-72.
• Smith E, De Young NJ, Pavey SJ, Hayward NK, Nancarrow DJ, Whiteman DC, Smithers BM, Ruszkiewicz AR, Clouston AD, Gotley DC, Devitt PG, Jamieson GG, Drew PA. Similarity of aberrant DNA methylation in Barrett’s esophagus and esophageal adenocarcinoma. Molecular Cancer 2008; 7: 75.
Conferences
• 4th Australian Medical and Health Research Congress, Brisbane, November 2008. Smith E, Kelly JJ, Jamieson GG and Drew PA. Antireflux surgery reduces aberrant DNA methylation in Barrett oesophagus.
• International Society for Diseases of the Esophagus, 11th World Congress, Budapest, September 2008. Kelly JJ, Jamieson GG, Myers JC, Smith E, Drew PA and Ruszkiewicz AR. Changes in oesophageal mucosa in patients 5 or more years after a fundoplication for Barrett’s oesophagus.
• International Society for Diseases of the Esophagus, 11th World Congress, Budapest, September 2008. Liu J-F, Jamieson GG, Wu T-C, Zhu G-J, Zhang S-W and Drew PA. A preliminary study on the post-operative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia.
Students Supervised
Mr E Smith - PhD
Mr JJ Kelly - Master of Surgery
Grants
• Cancer Council SA Research Grant (565194). GG Jamieson, PA Drew, E Smith, AR Ruszkiewicz, JJ Kelly, J-F Liu. “Improving diagnosis and treatment of reflux and cancer of the oesophagus by studying changes in microRNAs”. 2009 $72,250
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