Queen Elizabeth Hospital and Health Service

The Discipline of Orthopaedics and Trauma has continued research in Joint replacement in the areas of the outcome of prosthetic replacement following displaced femoral neck fracture in young patients, the effect of surgical approach on quadriceps function following total knee arthroplasty, a model for prediction of satisfaction in patients following total knee arthroplasty and outcome trials between the NexGen fixed bearing total knee replacement and the MBK mobile bearing total knee replacement, the Spectron and the Exeter total hip replacements and the TRAC PS mobile bearing total knee replacement and the establishment of an arthroplasty outcomes database. Knee replacements using the new Navigation method have recently been commenced.

In the area of oncologic research, the Discipline has been undertaking research in the functional results and health outcome of treating giant cell tumour, the natural history of enchondromas and the results of cement augmentation in the surgical management of enchondromas, intramuscular lipomas, hip replacement for metastatic disease, the results of the treatment of the anaemia of metastatic bone disease, the results of treating metastatic disease with the Russell-Taylor humeral nail, the presentation of a second primary in bone after visceral carcinoma, the results of radio-frequency ablation of osteoid osteomas and a comparative trial of neo-adjuvant chemotherapy versus neo-adjuvant radiotherapy for soft tissue sarcoma.

In the area of spinal disease, the Discipline has been undertaking research in the identification of risk factors for prolonged disability following whiplash, the effects of litigation on recovery following surgery for symptomatic lumbar prolapse, a prospective assessment of the use of autologous growth factors and coralline hydroxyapatite in spinal surgery and a retrospective evaluation of the use of Adcon-L gel in decompressive lumbar spine surgery.

Collaborative work has been undertaken in the areas of differential expression of alternatively spliced variants of the MDM2 oncogene product in bone tumours and sensitisation of cancer and sarcoma cells to TRAIL-induced apoptosis with chemotherapy.

Director
C Butcher MBBS FRACS FAOrthA

Senior Lecturer
MT Clayer MD MBBS FRACS FAOrthA up until 31st July 2002

Visiting Specialists
ET Mah MD BMBS FRACS FAOrthA
A Munyard MBBS FRCS FRACS FAOrthA
T Stevenson MBChB FRCS FRACS FAOrthA
G Morrison MBChB FRCS (Ed) FRACS FAOrthA
P Lewis MBBS FRACS FAOrthA
N Cullen MD FRCS(C) FRACS FAOrthA
O Osti MD PhD FRACS FAOrthA
D Waters BMBS FRACS
L Ferris MBBS FRACS

Spinal Research Fellow
H Nakamura MD PhD

Hand and Upper Limb Fellow
R Gupta MBBS, MS (Orth), DNBE (Orth), MNAMS, FAOI

Research Officers
P Lekkas BAppSc (Physio)

Postgraduate Student
C Gooi MS
Thesis: The Results of the Treatment of the Anaemia of Metastatic Bone Disease.

Current Research Activities

Lekkas P, Lewis P, Clayer M. T. Stevenson, G. Morrison, C. Butcher, D. Waters. A Comparative Trial between the NexGen Fixed Bearing Total Knee Replacement and the MBK Mobile Bearing Total Knee Replacement.

Lekkas P, Clayer M. T. Stevenson, G. Morrison, C. Butcher A Comparative Trial between the Spectron and the Exeter Total Hip Replacements.

Gooi C, Clayer M. The Results of the Treatment of the Anaemia of Metastatic Bone Disease.

Duncan W, Clayer M. The Presentation of a Second Primary in Bone after Visceral Carcinoma.

Lekkas P, Cullen N, Munyard A. The TRAC PS Mobile Bearing Total Knee Replacement Clinical Trial.

Lekkas P. A Retrospective Audit of the NexGen CR and MBK Total Knee Replacements.

Osti O. Identification of Risk Factors for Prolonged Disability following Whiplash.

Osti O. The Effects of Litigation on Recovery following Surgery for Symptomatic Lumbar Prolapse.

Osti O, Sebben R. Prospective Assessment of the use of Autologous Growth Factors and Coralline Hydroxyapatite in Spinal Surgery.

Nakamura, H, Osti O. Retrospective Evaluation of the use of Adcon-L Gel in Decompressive Lumbar Spine Surgery.

Lewis P, Lever, J, Butcher C J, Comparison of cutting jigs and navigation in accuracy of bone preparation in total knee replacements.

Further information is available at the Queen Elizabeth Hospital and Health Service website