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Obstetrics and GynaecologyThe University of Adelaide SA 5005 AUSTRALIA Telephone: +61 8 8303 5100 Facsimile: +61 8 8303 4099 |
Clinical InterestsThe environment surrounding the early mammalian embryo has a profound influence on the immediate and long-term developmental potential of the embryo. In particular, how embryos respond to in vitro culture environments continues to be my major research focus. A variety of techniques are utilized, in particular, microscopic fluorometric quantification is a useful tool to measure metabolic substrate levels and other biochemical markers of cellular stress and activity.
The transfer of research outcomes to clinical and industry application is also an important area of development. Improved knowledge of environment-oocyte/embryo interactions is used to improve oocyte maturation and embryo culture techniques. This in turn leads to more efficient in vitro embryo production for clinical infertility treatment or acceleration of superior genetic traits within industries such as dairy, meat and wool. Research involves a number of collaborations with other laboratories and also companies involved in the supply of artificial reproduction technologies.
Recent PublicationsNB: Impact factors in parentheses and numbers of citations > 5.0 per annum are identified. All data obtained from ISI Web of knowledge (http://isi10.isiknowledge.com).
Berg D.K., Thompson J.G. and Asher, G.W. (2002) Development of in vitro embryo production systems for red deer (Cervus elaphus). Part 2. The timing of in vitro nuclear oocyte maturation. Anim. Reprod. Sci. 70: 77-84. [1.68] Berg, D.K., Thompson, J.G. and Asher, G.W. (2002) Development of in vitro embryo production systems for red deer (Cervus elaphus). Part 1. Effect of epithelial oviductal monolayers and heparin on in vitro sperm motility and penetration of in vitro matured oocytes. Anim. Reprod. Sci. 70: 65-76. [1.68] deMatos, D.G, Gasparinni, B., Pasqualini, S.R. and Thompson, J.G. (2002) Effect of glutathione synthesis stimulation during in vitro maturation of ovine oocytes on embryo development and intracellular peroxide content. Theriogenology 57: 1443-1451. [2.39] Harvey, A.J., Kind K.L. and Thompson J.G. (2002) REDOX regulation of
embryo development. Reproduction 123: 479-486. [2.31], 9 citations (9.0/yr) Stojkovic M., Kölle S., Peinl S., Stojkovic P., Zakhartchenko V., Thompson J.G., Wenigerkind H., Reichenbach H-D., Sinowatz F. and Wolf E. (2002) Effects of high concentration of hyaluronan in culture medium on development and survival rates of fresh and frozen/thawed in vitro produced bovine embryos. Reproduction 124: 141-153. [2.31] Thompson, J.G., Kind, K., Roberts, C.T., Robertson, S.A. and Robinson J.S. (2002) Short and long-term consequences for the health of children conceived through ART – more reason for caution? Human Reproduction 17: 2783 – 2786 [3.25] Rieger, D., McGowan, L.T., Cox, S.F., Pugh, P.A. and Thompson, J.G. (2002) The effect of 2,4-dinitrophenol on the energy metabolism of cattle embryos produced by in-vitro fertilization and culture. Reprod. Fertil. Dev. 14: 339-343. [0.96] Sutton, M.L., Gilchrist, R.B. and Thompson, J.G. (2003) Effects of in vivo and in vitro environments on the metabolism of the cumulus-oocyte complex and influence on oocyte developmental capacity. Human Reproduction Update 9(1): 35-48 [3.71] Sutton, M.L., Cetica, P.D., Beconi, M.T., Kind, K.L., Gilchrist, R.B. and Thompson, J.G. (2003) Influence of oocyte-secreted factors and culture duration on the metabolic activity of bovine cumulus cell complexes. Reproduction 126:27-34 [2.31] Harvey, A.J., Kind, K.L., Pantaleon M, Armstrong D.T., and Thompson, J.G. (2004) Oxygen-regulated gene expression in bovine blastocysts. Biology of Reproduction (In Press) [3.64]. Sutton-McDowall, M.L., Gilchrist, R.B. and Thompson, J.G. (2004) Cumulus-expansion and glucose utilization by bovine cumulus-oocyte complexes during in vitro maturation: the influence of glucosamine and follicle stimulating hormone. Reproduction 128:313-319 [2.31] Harvey, A.J., Kind, K.L. and Thompson, J.G. (2004) Effect of oxidative phosphorylation uncoupler, 2, 4-dinitrophenol on hypoxia-inducible factor-regulated gene expression in bovine blastocyts. Reprod. Fertil. Dev. (In Press) [0.96] Kind, K.L., Collett, R.A., Harvey, A.J. and Thompson, J.G. (2004) Oxygen-regulated expression of GLUT-1, GLUT-3 and VEGF in the mouse blastocyst. Mol. Reprod. Dev. (In Press) [2.54]. Thomas, R.E., Thompson, J.G., Armstrong, D.T. and Gilchrist, R.B. (2004) Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity. Biology of Reproduction 17 (In Press) [3.64]. Thompson, J.G. (2004) A mixed bag: A perspective on the regulation of IVF in Australia. Human Fertility. (In Press)
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