Alastair H MacLennan Professor of Obstetrics and Gynaecology Head of Discipline MBChB (Glasgow), MD (Glasgow), FRCOG (London), FRANZCOG (Melbourne) Email: alastair.maclennan@adelaide.edu.au Contact information Websites: ARCH, Cerebral Palsy

Other Senior Appointments

• Joint Editor in Chief "Climacteric" , Journal of the International Menopause Society
• Past President Australian Perinatal Society
• Past President Australian Menopause Society
• Visiting Senior Medical Specialist, Women's & Children's Hospital, Adelaide
• Head, University Menopause Clinic and Menopause Research Group
• Head of South Australian Cerebral Palsy Research Group

Research Interests

Reproductive Endocrinology and Feto-Maternal Medicine. Author of 3 books, 26 chapters and over 300 publications. Laboratory and clinical trial research has been conducted on many aspects of the hormones relaxin, prostaglandins E2 and F2 a, oestrogen and progestogens. Feto-Maternal research includes preterm labour, cervical ripening, pelvic joint laxity and multiple pregnancy.  Cerebral palsy, causation and its medico legal aspects and the effective delivery of obstetric care are all current Research interests. His ongoing research is on genetic susceptibility factors for cerebral palsy that interact with environmental risk factors for cerebral palsy eg. infection, growth restriction

Research in the menopause and climacteric includes epidemiological studies on the menopause, its conventional and alternative management and many randomised controlled trials of new hormone replacement therapies. Professor MacLennan is a member of the Cochrane Collaboration Review Group on Menstrual Disorders and is conducting and has published systematic reviews on hormone replacement therapies.  He was Chairman of the Women's International Study on Long Duration Oestrogen after Menopause (WISDOM) in Australia .  He is currently conducting long-term trials on tibolone after breast cancer (LIBERATE) and the influence of hormone therapies on cognitive function in ageing women (REMEMBER).

Education

Professor MacLennan has a special interest in video education and has made over 30 educational videos for the lay public, students and specialists.  He is very involved with postgraduate education and has run many national and international congresses. He supervises PhD and Honours Science students as well as medical students.

Clinical Interest

A general public and private gynaecological practice continues with special interest in the menopause.   

Recent Key Publications

Books

MacLennan AH, MacLennan A. Presenting a positive outlook on the menopause. Published by Wyeth Ayerst first in 1991. Now in 16 th Edition 2008. Two million copies distributed.

Recent Chapters in Scientific Books

1. MacLennan AH. Pelvic girdle relaxation, developmental dysplasia of the hip and the hormone relaxin ? are they loosely connected? In Relaxin 2000
2. Tregear GW, Ivell I, Bathgate RA,Wade JD[Eds]. Kluwer Academic Publishers, Dordrecht , 2002, 407-413.
3. MacLennan AH, Tregear GW. Relaxin in the new millennium. In Relaxin 2000 Treagear GW, IvellI, Bathgate,RA, Wade JD{Eds]. Kluwer Academic Publishers, Dordrecht , 2002,441-451.
4. MacLennan AH. Foreword to Neonatal Encephalopathy and Cerebral Palsy . Defining the Pathogenesis and Pathophysiology. A report by the American College of Obstetricians and Gynecologists Task Force on Neonatal Encephalopathy and Cerebral Palsy and the American College of Obstetricians and Gynecologists and the American Academy of Pediatrics. 2003; xi-xii.
5. MacLennan AH. The menopause and beyond. In Women's Health. A Core Curriculum. Finn M, Bowyer L, Carr S, O'Connor V, Vollenhoven B [Eds]. Elsevier Sydney 2005; 235-243.

Recent Refereed Journal Articles

1. Gibson CS, MacLennan AH, Goldwater PN, Dekker GA. Antenatal Causes of Cerebral Palsy: Associations between inherited thrombophilias, viral and bacterial infection, and inherited susceptibility to infection. Obstet Gynecol Surv 2003; 58: 209-220.
2. MacLennan AH, SturdeeDW. Is hormone therapy still an option for the management of osteoporosis? Climacteric 2003; 6: 89-91.
3. Sturdee DW, MacLennan AH. Is combined estrogen/progestogen hormone therapy worth the risk? Climacteric 2003; 6: 177-179.
4. MacLennan AH, Sturdee DW. Time for new long-term trials of postmenopausal hormone therapies! Climacteric 2003; 6: 265-267.
5. MacLennan AH. Contributor to the position statement of the North American Menopause Society on the treatment of menopause-associated vasomotor symptoms. Menopause 2004; 11: 11-33.
6. Avery JC, Gill TK, MacLennan AH, Chittleborough CR, Grant JF, Taylor AW. The impact of incontinence on health-related quality of life in a South Australian population sample. Aust N Z J Public Health 2004; 28: 173-9.
7. MacLennan AH, Robinson J. Cerebral palsy and clinical negligence litigation: a cohort study. Br J Obstet Gynaecol 2004; 111: 92-93.
8. Sturdee D, MacLennan AH. Should epidemiology, the media and quangos determine clinical practice? Climacteric 2004; 7: 1-2.
9. Paine BJ, Stocks NP, Ramsay EN, Ryan P, MacLennan AH for the WISDOM Australia Research team. Use and perception of hormone therapy following media reports of the Women's Health Initiative: a survey of Australian WISDOM participants. Climacteric 2004; 7: 143-152.
10. MacLennan AH, Taylor AW, Wilson DH. Hormone therapy use after the Women's Health Initiative. Climacteric 2004; 7: 138-142.
11. MacLennan AH, Sturdee DW. Publishing the results of the estrogen-only arm of WHI. Climacteric 2004; 7: 117-119.
12. MacLennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. The Cochrane Database of Systematic Reviews2004, Issue 4. Art. No.: CD002978. DOI: 10.1002/14651858.CD002978.pub2
13. MacLennan AH, Sturdee DW. WHI, WHI, WHI? Climacteric 2004; 7: 221-224.
14. O'Neill S, MacLennan AH, Bass S, Diamond T, Ebling P, Findlay D, Flicker L, Markwell A, Nowson C, Pocock N, Sambrook P, Singh MF. Guidelines for the management of postmenopausal osteoporosis for GPs. Aust Fam Physician 2004; 33: 910-917.
15. Sturdee DW, MacLennan AH. Evolution and revolution at the menopause. Climacteric 2004; 7: 325-326.
16. MacLennan AH, Sturdee DW. Clarifying the interpretations of data from the Women's Health Initiative trial. O & G. Journal of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists. 2004; 6: 298-300.
17. O'Neill S, MacLennan AH, Bass S, Diamond T, Ebling P, Findlay D, Flicker L, Maxwell A, Nowson C, Pockock N, Sambrook P, Singh MF. Guidelines for the management of postmenopausal osteoporosis for GPs. Osteoblast. 2005; 4(Supplement): 3-11.
18. MacLennan AH, Sturdee DW. Towards safer women, safer doses, safer routes and safer timing of administration of safer menopausal therapies. Climacteric 2005; 8: 1- 2.
19. Gibson CS, MacLennan AH, Rudzki Z, Hague WM, Haan EA, Sharpes P, Priest K, Chan A, Dekker GA. The prevalence of inherited thrombophilias in a Caucasian Australian population. Pathology 2005; 37(2): 160-163.
20. Sturdee DW, MacLennan AH. Prevention of osteoporosis is still a valid aim for hormone therapy. Climacteric 2005; 8: 97-98.
21. MacLennan AH, Nelson KB, Hankins G, Speer M. Who will deliver our grandchildren? Implications of Cerebral Palsy litigation. JAMA 2005; 294: 1688-90.
22. Gibson CS, MacLennan AH, Hague WM, Haan EA, Priest K, Chan A, Dekker GA for the South Australian Cerebral Palsy Research Group. Associations between inherited thrombophilias, gestational age, and cerebral palsy. Amer J Obstet Gynecol 2005; 193: 1437.el-1437.e12.
23. MacLennan AH, Henderson VW, Paine BJ, Mathias J, Ramsay EN, Ryan P, Stocks NP, Taylor AW. Hormone therapy, Timing of Initiation, and Cognition in Women aged over 60 years – The REMEMBER pilot study. Climacteric 2005; 8(Supplement 2): 103 (abstract).
24. Norman RJ, MacLennan AH. Current status of hormone therapy and breast cancer. Hum Reprod Update 2005; 11: 541-3.
25. Sturdee DW, MacLennan AH. How low can you go? Climacteric 2005; 8: 305-6.
26. MacLennan AH, Myers SP, Taylor AW. The continuing use of complementary and alternative medicine in South Australia : costs and beliefs in 2004. Med J Aust 2006; 184: 27-31.
27. Gibson CS, MacLennan AH, Goldwater PN, Haan EA, Priest K, Dekker GA , for the South Australian Cerebral Palsy Research Group. Neurotropic viruses and cerebral palsy: population based case-control study. BMJ, doi:10.1136/bmj.38668.616806.3A (published 6 January 2006).
28. MacLennan AH, Sturdee DW. The “Bioidentical/bioequivalent” hormone scam. Climacteric 2006; 9: 1-3.
29. MacLennan AH, Henderson VW, Paine BJ, Mathias J, Ramsay EN, Ryan P, Stocks NP, Taylor AW. Hormone therapy, timing of initiation, and cognition in women older than 60 years: the REMEMBER pilot study. Menopause 2006; 13: 28-36.
30. MacLennan AH. A 41-year-old woman with Premature Menopause. Medicine Today 2006; 7: 62-63.
31. Gibson CS, MacLennan AH, Goldwater PN, Haan EA, Priest K, Dekker GA for the South Australian Cerebral Palsy Research Group. The association between inherited cytokine polymorphisms and cerebral palsy. Amer J Obstet Gynecol 2006; 194: 674.e1-674.e11.
32. MacLennan AH, Hankins G, Speer M. Only an expert witness can prevent cerebral palsy! O & G 2006; 8: 28-30.
33. Sturdee DW, MacLennan AH. The pendulum swings back: Estrogen is beneficial now if started at the right time. Climacteric 2006; 9: 71-72.
34. Strijbis EMM, Oudman I, van Essen P, MacLennan AH. Cerebral palsy and the application of the international criteria for acute intrapartum hypoxia. Obstet Gynec 2006; 107: 1357-1365.
35. Hankins GD, MacLennan AH, Speer ME, Strunk A, Nelson K. Obstetric litigation is asphyxiating our maternity services. Obstet Gynec 2006; 107:1382-1385.
36. Gibson CS, MacLennan AH, Janssen NG, Kist WJ, Hague WM, Haan EA, Goldwater PN, Priest K, Dekker GA for the South Australian Cerebral Palsy Research Group. Associations between fetal inherited thrombophilia and adverse pregnancy outcomes. Amer J Obstet Gynecol 2006; 194, 947.e1-947.e10
37. MacLennan AH, Sturdee DW. The use and abuse of screening tests around menopause. Climacteric 2006; 9: 153-155.
38. Taylor AW, MacLennan AH, Avery JC. Postmenopausal hormone therapy: Who now takes it and do they differ from non-users? Aust NZ J Obstet Gynaec 2006; 46:128-135.
39. O'Neill S, MacLennan AH, Bass S, Diamond T, Ebling P, Findlay D, Flicker l, Markwell A, Nowson C, Pockock N, Sambrook P, Singh MF. Wytyczne postepowania z osteopooza pomenopauzalna dla lekarzy rodzinnych. Lekarz Rodzinny 2006; 104 (4): 444-455.
40. Sturdee DW, MacLennan AH. Reducing the problems of the progestogen. Climacteric 2006; 9: 241-243.
41. Conlin M, MacLennan AH, Broadbent J. Inadequate compliance with periconceptional folic acid supplementation in South Australia . Aust NZ J Obstet Gynaec 2006; 46: 528-533.
42. MacLennan AH, Sturdee DW. Is endometrial monitoring required with the use of long-term unopposed vaginal estrogen? Climacteric 2006; 9: 321-322.
43. Gibson CS, MacLennan AH, Dekker GA, Goldwater PN, Dambrosia JM, Munroe DJ, Tsang S, Stewart C, Nelson KB. Genetic Polymorphisms and Spontaneous Preterm Birth. Obstet Gynecol 2007; 109: 384-391.
44. MacLennan AH, Sturdee DW. Long-term trials of HRT for cardioprotection – is this as good as it gets? Climacteric 2007; 10: 1-4.
45. Sturdee DW, MacLennan AH. The weight problem. Climacteric 2007; 10: 83-84.
46. Maclennan AH, Sturdee DW. Time for mandatory labelling of over-the-counter medicines. Climacteric 2007; 10: 179-180.
47. Vickers MR, Martin J, Meade TW and the WISDOM Study Team. The Women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial. BMC Women's Health 2007, 7:2: http://www.biomedcentral.com/1472-6874/7/2 .
48. Board of the International Menopause Society (MacLennan AH, co-author). IMS Updated recommendations on postmenopausal hormone therapy. Climacteric 2007; 10: 181-194.
49. MacLennan AH. HRT –A reappraisal of the risks and benefits. Med J Aust 2007; 186: 643 - 646.
50. Vickers MR, MacLennan AH, Lawton B, Ford D, Martin J, Meredith SK et al. Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women. BMJ 2007; doi:10.1136/bmj.39266.425069.AD (published 12/7/07). http://www.bmj.com/cgi/content/full/bmj.39266.425069.AD Abridged print version BMJ 2007; 335: 239-244.
51. Pines A, Sturdee DW, MacLennan AH, Schneider HPG, Burger H, Fenton A. The heart of the WHI study: time for hormone therapy policies to be revised. Climacteric 2007; 10: 267-269.

Audiovisual

Available from Prof Alastair MacLennan,
University Department of Obstetrics and Gynaecology,
1/F Queen Victoria Building,
Women's & Children's Hospital,
North Adelaide, SA 5006.  Phone (61 8) 8161 7619

1. The Politics of Female Health - Women and Cardiovascular Disease
2. Hormone Replacement Therapy After Breast Cancer
3. Cerebral Palsy. Who is to Blame? - Expert opinion versus evidence based medicine
4. Video Highlights of the 1987, 1990, 1993 and 1996 International Menopause Congresses in Sorrento, Bangkok, Stokholm and Sydney
5. Understanding the Menopause
6. Modern Management of the Menopause
7. Menopause Update
8. MacLennan, A.H., MacLennan, A. Menopause Messages: highlights of the 8th International Congress on the Menopause (Sydney, Australia, November 1996). Adelaide Women's and Children's Hospital: Foundation Studios, 1997.
9. MacLennan, A.H. The Menopause and HRT (Educational audiotape). Sydney, NSW: Drivetime Radio, 1997.
10. MacLennan, A.H. The menopause: appropriate management with HRT (edn 37 - audiotape). Sydney, NSW: Drivetime Radio, 1997.
11. MacLennan, A.H. Hormone Replacement Therapy in Perspective (edn 39 - audiotape). Sydney, NSW: Drivetime Radio, 1997.
12. MacLennan, A.H. Reproductive technology - an experiment with style. Video (55 minutes) - edited scientific hypothetical debate at the Fertility Society of Australia. Adelaide Women's and Children's Hospital: Foundation Studios, 1998.
13. MacLennan, A.H., MacLennan, A., Sprod, R. Menopause, Evidence-based answers to your questions. Video. Dept of Obstetrics and Gynaecology, The University of Adelaide, 2003

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