Dr Sandra Peake

Graduated B.Sc.(Hons) from Melbourne University in 1978, then BMBS from Flinders University in 1983. Attained the FFARACS (Intensive Care) in 1991, FFICANZCA in 1993 and admitted as a Foundation Fellow, FJFICM 2002. Awarded a PhD from Adelaide University in 2001.

Clinical Interests:

• Training and Education (Currently Supervisor of Training at TQEH).
• Part II Examiner JFICM.
• Research (see publications below)
• Sepsis in ICU

Contact:

• Ph:        +61 8 8222 6463
• Fax:      +61 8 8222 6045
• e-Mail:   Sandra.Peake@nwahs.sa.gov.au

Other Interests:

• Raising 2 children.

Publications:

1. Peake S, Roxburgh H, Langlois S: Ultrasonic Assessment of Hydronephrosis of Pregnancy. Radiology 1983;146(1):167-170
2. Peake SL, Bihari DJ: Monoclonal antibodies - A new era in diagnosis and treatment: Care of the Critically Ill 1992;8:5-6
3. Bihari D, Smithies M, Beale R, Peake S, Maynard N: Regional blood flow: Can the intensive care physician do more? Clinical Intensive Care 1992;3(1):38S-41S
4. Peake SL, Pavia JA, Bihari DB, Chambers JB: An uncommon cause of acute right ventricular failure and high mixed venous oxygen saturation. Intensive Care Medicine 1992;18:368-370
5. Peake SL: Monoclonal antibodies - Immunotherapy for the critically ill. Anaesthesia and Intensive Care 1993;21:739-751
6. Peake SL: Advances in the treatment of septic shock: The quest for the holy grail?: Australasian Anaesthesia 1993;173-186
7. Moran JL, Gallagher J, Peake SL, Cummingham DN, Salagaras M, Leppard P: Parenteral magnesium sulphate versus amiodorone in the therapy of atrial tachyarrythmias: a prospective, randomised study. Critical Care Medicine 1995;23:1816-1824
8. Duffy BL, Harding JN, Fuller WR, Peake SL: Cardiac arrest following Haemaccel. Anaesthesia and Intensive Care 1994;22:90-92
9. Peake SL, Moran JL, Leppard PI: N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock. Critical Care Medicine 1995;23:1302-1310
10. Chapman M, Peake SL. Immune dysfunction associated with critical illness. Oxford textbook of critical care. Webb AR, Shapiro MJ, Singer M, Suter PM (Ed). Oxford Medical Publications; Oxford University Press 1999;Chapter 13.4.2, pp 894-897
11. Peake SL, Fisher M. Immunotherapy. Oxford textbook of critical care. Webb AR, Shapiro MJ, Singer M, Suter PM (Ed). Oxford Medical Publications; Oxford University Press 1999;Chapter 17.1.17, pp 1249-1252
12. Peake SL, Pierides J, Leppard PI, Russ GR. Anti-ovine interleukin-1 monoclonal antibody immunotherapy in an ovine model of gram-negative septic shock. Crit Care Med 2002;30:171-181
13. Moran JL, Peake SL, Solomon P. Reporting of clinical trials using group sequential methods. Crit Care Resusc 2001;3:141-147
14. Peake SL. Pierides J, Leppard PI. Combination anti-cytokine immunotherapy in an ovine model of E.coli-induced septic shock. Am J Respir Crit Care Med, submitted
15. Moran JL, Peake SL, Further reflections on clinical trials in critical care. Crit Care Resusc 2001;4:226-228
16. Moran JL, Peake SL. Early enteral nutrition support improves outcome: hypothesis or fact? Crit Care Resusc 2002;4:7-17
17. Moran JL, Peake SL, Solomon P. Hypothermia as therapy in critical injury. Crit Care Resusc 2002;4:86-92
18. Moran JL, Peake SL, Solomon P. Learning lessons or repeating old mistakes? Crit Care Resusc 2002;4:257-260

Published Abstracts of Presentations

1. Peake SL, Russ GR: A reproducible model of lethal hyperdynamic gram-negative shock in awake sheep. European Respiratory Journal 1993;6(S17):300S
2. Homan SDR, Moran JL, Peake SL: Factors influencing the performance of continuous positive airway pressure circuits in normal subjects and test lungs. European Respiratory Journal 1993;6(S17):302S
3. Peake SL, Moran JL, Smith D: Plasma nitrate and nitrite levels in septic shock. Anaesthesia and Intensive Care 1994;22:226-227
4. Moran JL, Homan S, Peake SL: The performance of continuous positive airway pressure breathing systems in new generation microprocessor controlled ventilators. Anaesthesia and Intensive Care 1994;22:229-230
5. Peake SL, Moran JL, Leppard P: Monoethylglycinexylidide (MEGX) formation in septic shock: an early indicator of hepatic dysfunction? 7th European Congress in Intensive Care Medicine Innsbruk 1994 Intensive Care Medicine 1994;20(S2)
6. Moran JL, Gallagher J, Peake SL, Cunningham DN, Salagaras M: Treatment of atrial tachyarrythmias in the critically ill: intravenous magnesium sulphate versus amiodorone. Intensive Care Medicine 1994;20(S2):S116
7. Moran JL, Homan, Peake SL, Smith D: Factors determining the work of breathing of continuous positive pressure breathing systems in new generation microprocessor controlled ventilators. Respiratory and Critical Care Medicine 1994;149:A68
8. Salagaras M, Homan SDR, Moran JL, Peake SL: Nasal intermitttent positive pressure ventilation: a physiologic evaluation. European Respiratory Journal 1994:(Suppl 18):S416
9. Peake SL, Carter JK, Russ GR. Prophylactic anti-interleukin-1 monoclonal antibody therapy in ovine septic shock. Anaesthesia and Intensive Care 1996;
10. Peake SL, Carter JK, Porter K, Russ GR. Is combination immunotherapy superior to monotherapy in septic shock? Anaesthesia and Intensive Care 1998;26:446-447
11. Peake SL, Russ GR, Leppard PI. Are animal models of septic shock stable over time? Anaesthesia and Intensive Care 2001;29:190-191
12. Moran JL, Peake SL, Warn D. Meta-analysis of treatment effects in intensive care practice: the case for further analysis. Anaesthesia and Intensive Care 2001;29:192-193
13. Salagaras M, Peake SL, Grealy B, Moran JL, Peisach AR, Peter JV. Normalisation of body temperature as a predictor of survival. Anaesthesia and Intensive Care 2001;29:199
14. Moran JL, Fox V, Salagaras M, Williams P, Quinlan K, Peake SL. Thirty day outcome of acute respiratory distress syndrome (ARDS) in mechanically ventilated patients. Intensive Care Med 2001;Supplement 2;S160
15. Moran JL, Peake SL, Warn D. Heterogeneity of treatment effects in meta-analysis of intensive care practice. Intensive Care Med 2001;Supplement 2:S170
16. Peake SL, Moran JL, Fox V, Lorchirachoonkul T. Acute cardiogenic pulmonary oedema: in-hospital and long-term outcome after ICU admission. Intensive Care Med 2001;Supplemenmt 2:S282
17. Peake SL, Moran JL, Lloyd AJ, Walker M. The effect of body mass index on outcome in critically ill patients. Anaesthesia and Intensive Care 2003 (in press).

Presentations

1. Peake SL, Crowley K: Central Hyperthermic Muscular Rigidity Syndromes: 15th Australian and New Zealand Scientific Meeting on Intensive Care, Adelaide, Australia 1990
2. Bihari D, Smithies M, Beale R, Peake SL et al: The impact of organisational and policy changes on the cost performance profile of an intensive care unit. 17th Australian and New Zealand Scientific Meeting on Intensive Care, Auckland. New Zealand 1992
3. Peake SL, Carter JK, Russ GR: A reproducible model of lethal hyperdynamic gram-negative shock in awake sheep. European Respiratory Society 3rd Annual Congress, Florence, Italy 1993
4. Homan SDR, Moran JL, Peake SL: Factors influencing the performance of continuous positive airway pressure circuits in normal subjects and test-lung. European Respiratory Society 3rd Annual Congress, Florence, Italy 1993
5. Peake SL, Moran JM, Smith D: Plasma nitrate and nitrite levels in septic shock. 18th Australian and New Zealand Scientific Meeting on Intensive Care, Perth, Australia 1993
6. Moran JL, Homan SDR, Peake SL, Smith D: The performance of continuous positive pressure breathing systems in new generation microprocessor controlled ventilators. 18th Australian and New Zealand Scientific Meeting on Intensive Care, Perth, Australia1993
7. Salagaras M, Homan S, Moran JL, Peake SL: Nasal intermittent positive pressure ventilation - a physiologic evaluation.18th Australian and New Zealand Scientific Meeting on Intensive Care, Perth, Australia 1993
8. Peake SL, Carter JK, Russ GR: A reproducible model of lethal hyperdynamic gram-negative shock in awake sheep. 19th Australian and New Zealand Scientific Meeting on Intensive Care, Sydney, Australia 1994
9. Moran JL, Gallagher JV, Peake SL, Cunningham DN, Salagaras M, Leppard PI: Parenteral magnesium sulphate versus amiodorone in the therapy of atrial tachyarrythmias: a prospective, randomised study. 19th Australian and New Zealand Scientific Meeting on Intensive Care, Sydney, Australia 1994
10. Moran JL, Homan S, Peake SL, Smith D: Modelling work of breathing: the effects of continuous positive pressure, endotracheal tube size and inspiratory flow in normal subjects and test lung. 19th Australian and New Zealand Scientific Meeting on Intensive Care, Sydney, Australia 1994
11. Peake SL, Moran JL, Leppard PI: N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock. 19th Australian and New Zealand Scientific Meeting on Intensive Care, Sydney, Australia 1994
12. Peake SL, Morris, Leppard PI: Monoethylglycinexylidide (MEGX) formation in septic shock: an early indicator of hepatic dysfunction? 19th Australian and New Zealand Scientific Meeting on Intensive Care, Sydney, Australia 1994
13. Moran JL, Homan SD, Peake SL, Smith D: Airway pressure, endotracheal tube size and inspiratory flow in normal subjects and test-lung. 19th Australian and New Zealand Scientific Meeting on Intensive Care, Sydney, Australia 1994
14. Moran J, GallagherJ, Peake SL, Cunningham DN, Salagaras M: Treatment of atrial tachyarrythmias in the critically ill: intravenous magnesium sulphate versus amiodorone. 7th European Congress in Intensive Care Medicine Innsbruk, Austria 1994
15. Peake SL, Morris, Leppard PI: Monoethylglycinexylidide (MEGX) formation in septic shock: an early indicator of hepatic dysfunction? 7th European Congress in Intensive Care Medicine Innsbruk, Austria 1994
16. Homan SDR, Moran JL, Peake SL, Smith D: Modelling work of breathing:the effects of continuous positive airway pressure, endotracheal size and inspiratory flow in normal subjects and test lung. 5th Annual Meeting of European society for Computing and Technology in Anaesthesia and Intensive Care Porto Carras-Haraldiki, Greece 1994
17. Salagaras M, Homan S, Moran JL, Peake SL: Nasal intermittent positive pressure ventilation: A physiologic evaluation. European Respiratory Society 4th Annual Congress, Nice, France 1994
18. Moran JL, Homan SDR, Peake SL, Smith D: Factors determining the work of breathing of continuous positive pressure breathing systems in new generation microprocessor controlled ventilators. American Thoracic Society International Conference, Boston, USA 1994
19. Peake SL, Moran JL, Leppard PI: N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock. 5th Vienna Shock Forum, Vienna, Austria 1995
20. Peake SL, Carter JK, Russ GR. Prophylactic Anti-interleukin-1 monoclonal antibody therapy in ovine septic shock. The 20th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Brisbane, Australia 1995
21. Peake SL, Carter JK, Porter K, Russ GR. Is combination immunotherapy superior to monotherapy in septic shock? The 22nd Australian and New Zealand Annual Scientific Meting on Intensive Care, Hobart, Australia 1997
22. Rowley KM, Salagaras M, Moran JL, Peake SL. Comparison of pulse oximetry and arterial blood gas measurements in critically ill patients. The 23rd Australian and New Zealand Annual Scientific Meeting on Intensive Care, Adelaide, 1998
23. Peake SL, Russ GR, Leppard PI. Are animal models of septic shock stable over time? The 25th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Canberra, Australia 2000
24. Moran JL, Peake SL, Warn D. Meta-analysis of treatment effects in intensive care practice: the case for further analysis. The 25th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Canberra, Australia 2000
25. Salagaras M, Peake SL, Grealy B, Moran JL, Peisach AR, Peter JV. Normalisation of body temperature as a predictor of survival. The 25th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Canberra, Australia 2000
26. Fung C-L, Moran JL, Fox V, Salagaras M, Williams P, Quinlan K, Peake SL. Thirty-day outcome from onset of acute respiratory distress syndrome in mechanically ventilated patients in an adult intensive care. The 25th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Canberra, Australia 2000
27. Moran JL, Fox V, Salagaras M, Williams P, Quinlan K, Peake SL. Thirty day outcome of acute respiratory distress syndrome (ARDS) in mechanically ventilated patients. European Society of Intensive Care Medicine 14th Annual Congress, Geneva, Switzerland 2001
28. Moran JL, Peake SL, Warn D. Heterogeneity of treatment effects in meta-analysis of intensive care practice. European Society of Intensive Care Medicine 14th Annual Congress, Geneva, Switzerland 2001
29. Peake SL, Moran JL, Fox V, Lorchirachoonkul T. Acute cardiogenic pulmonary oedema: In hospital and long-term outcome after ICU admission. European Society of Intensive Care Medicine 14th Annual Congress, Geneva, Switzerland 2001
30. Peake SL, Lloyd AJ, Moran JL. The effect of obesity on outcome in critically ill patients. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Perth, Australia 2002

Invited Lectures

1. Peake SL: Monoclonal antibodies - Immunotherapy for the critically ill. The 17th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Auckland, New Zealand 1992
2. Peake SL: Use of monoclonal antibodies in sepsis. Annual Scientific Meeting Royal Australasian College of Surgeons and Australian and New Zealand College of Anaesthetists, Adelaide, Australia 1993
3. Peake SL: The role of nitric oxide in septic shock. 4th Continuing Education Meeting on Intensive Care, Australian and New Zealand Intensive Care Society (South Australia), Adelaide, Australia 1994
4. Peake SL, Morris, Leppard PI: Monoethylglycinexylidide (MEGX) formation in septic shock: an early indicator of hepatic dysfunction? 5th Vienna Shock Forum, Vienna, Austria 1995
5. Peake SL. Colloids – do they have a current role in resuscitation? Annual Scientific Meeting, Faculty of Intensive Care, Australian and New Zealand College of Anaesthetists, Melbourne 2000
6. Peake SL. Colloid therapy – evidence for and against. Continuing Education Meeting, Australian College of Critical Care Nurses (South Australia), Adelaide 2000
7. Peake SL. Multiple mediators – Multiple bullets? Prince of Wales bimonthly meeting. Sydney, Australia 2001
8. Peake SL. Pseudomonas outbreaks. The 27th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Perth, Australia 2002
9. Peake SL. Interpretation and assessment of clinical trials in sepsis. Intensive Care and Emergency Medicine Symposium, Sydney, Australia 2002

Awards & Scholarships

• National Health and Medical Research Council medical post-graduate research scholarship 1992 - 1995
• Monoclonal antibodies - Immunotherapy for the critically ill. Tag/Bird Best Medical Review Prize. 17th Australian and New Zealand Scientific Meeting on Intensive Care, Auckland 1992
• Australian and New Zealand Intensive Care Foundation Grant 1995 ($13,800)
• Peake SL, Russ GR, Leppard PI. Are animal models of septic shock stable over time? Best Basic Science Paper. The25th Australian and New Zealand Annual Scientific Meeting on Intensive Care, Canberra, Australia 2000.