Dr Mounir N Ghabriel

• MBBCh (Egypt), PhD (London)

• Associate Professor of Anatomy

Location	Room 125, Medical School North Building
E-mail	mounir.ghabriel@adelaide.edu.au
Telephone	08 8303 5481
Fax

Teaching

Mounir has a strong interest in teaching with over twenty-years experience in teaching human anatomy to undergraduate and postgraduate students. He taught anatomy at universities in Europe, Australia, Africa and America. Current teaching responsibilities to undergraduate and postgraduate students include: lectures, practical demonstrations in the dissecting laboratory, small group tutorials and case-based teaching / clinical correlation in gross anatomy, neuroanatomy and embryology to medical, dental, physiotherapy, occupational therapy, health science and science students.

Research Interests

Mounir is the head of the Blood-Brain Barrier Group. He is interested in the structure and function of the central and peripheral nervous systems in normal and pathological conditions such as demyelination, degeneration and trauma. A focus of the group's research is the study of permeability barriers in brain and spinal cord trauma. The methodology includes the use of light and electron microscopy, freeze-fracture, immunocytochemistry, application of tracers and western-blotting.

The Blood-Brain Barrier Group consists of :
Dr Mounir Ghabriel
Dr Rami Tadros
Dr Jianjun Lu
Mrs Gail Hermanis
Mr Chris Leigh
Ms Irena Zdziarski
Mrs Heidi Magar
Miss Amber Thomas
Mr YuChao Lee
Miss Dawn Lee
Mr Abdul Imran

Collaborators

Mounir has current collaborative projects with:

Within the discipline
Professor Brian Setchell, Reproductive Biology Group
Dr Bruce Firth, Circadian Rhythm Group

External:
Professor Peter Blumbergs and Associate Professor Robert Vink, Neurotrauma group, The Institute of Medical and Veterinary Science, Adelaide.
Professor Nigel Jones and Professor Peter Reilly, Department Neurosurgery, The University of Adelaide ( Medical School)
Dr Chunni Zhu, Department of Medicine, School of Medicine, UCLA, CA, USA.

Recent Publications 2002-2009

1. Ghabriel MN, Zdziarski IM, Leigh C, Vink R (2008) Changes in the blood-CSF barrier in experimental traumatic brain injury. Acta Neurochir (in press)
2. Cai Z, Finnie JW, Blumbergs PC, Manavis J, Ghabriel MN, Thompson PD (2006) Early paranodal myelin swellings (tomacula) in an avian riboflavin deficiency model of demyelinating neuropathy. Experimental Neurology 198: 65-71.
3. Ghabriel MN, Thomas A, Vink R (2006) Magnesium restores altered aquaporin–4 immunoreactivity following traumatic brain injury to a preinjury state. Acta Neurochirurgica Suppl. 96: 402-406.
4. Cai Z, Blumbergs PC, Cash K, Rice PJ, Manavis J, Swift J, Ghabriel MN, Thompson PD (2005) Paranodal pathology in Tangier disease with remitting-relapsing multifocal neuropathy. Journal of Clinical Neuroscience 13: 492-497.
5. Yang L, Jones NR, Blumbergs PC, Van Der Heuvel C, Moore EJ, Manavis J, Sarvestani GT and Ghabriel MN (2005) Severity-dependent expression of proinflammatory cytokines in traumatic spinal cord injury in the rat. Journal of Clinical Neuroscience 12: 276-284.
6. Bhatia K, Ghabriel MN, Henneberg M (2005) Anatomical variations in the branches of the human aortic arch: a recent study of a South Australian population. Folia Morphologica 64: 217-223.
7. Ghabriel M, Zhu C, Imran A, Blumbergs P and Reilly P (2004) Blood-brain barrier ultrastructural changes in impact acceleration head trauma. Proceedings of the 7th international Neurotrauma Symposium, Adelaide, Australia, pp 89-92, Medimond International Proceedings, Bologna, Italy. ISBN 88-7587-082-9.
8. Peppi M, Ghabriel MN (2004) Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands. Journal of Anatomy 205: 257-266.
9. Cai Z, Blumbergs PC, Koblar SA, Cash K, Manavis J, Ghabriel MN, Thompson PD (2004) Peripheral nervous system and central nervous system pathology in rapidly progressive lower motor neurone syndrome with immunoglobulin M anti-GM1 ganglioside antibody. Journal of the peripheral nervous system 9: 79-91.
10. Ghabriel MN, Lu J, Tadros R and Hermanis G (2004) A narrow time-window for access to the brain by exogenous protein after immunological targeting of a blood-brain barrier antigen. Journal of Comparative Pathology 131: 52-60.
11. Yang L, Blumbergs PC, Jones NR, Manavis J, Sarvestani GT, Ghabriel MN (2004) Early expression and cellular localization of proinflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α in human traumatic spinal cord injury. Spine 29: 966-971.
12. Ghabriel MN, Zhu C, Leigh C (2002) Electron microscope study of blood-brain barrier opening induced by immunological targeting of the endothelial barrier antigen. Brain Research 934: 140-151.
13. Ghabriel MN, Lu JJ, Hermanis G, Zhu C and Setchell BP (2002) Expression of a blood-brain barrier-specific antigen in the rat male reproductive tract. Reproduction 123: 389-397.

Abstracts and conference presentation

1. Ghabriel MN, Zdziarski IM, Leigh C, Vink R (2009) Ultrastructural changes in choroidal epithelial cells in traumatic brain injury. Proceedings of the Australian Neuroscience Society, Vol 19, Poster 261.
2. Ghabriel MN, Zdziarski IM, Leigh C, Vink R (2008) Changes in the blood-CSF barrier in experimental traumatic brain injury. Proceedings of the 14th International symposium on Brain oedema and brain tissue injury, June 11-14, 2008 Warsaw Poland.
3. Ghabriel MN, Lu JJ, Lim WH, Setchell BP (2005) Effects of moderate spinal cord injury on the expression of a barrier marker in endothelial cells of the testis and in the prostate of rats. Reproduction, Fertility and Development, 17 (Supplement), p. 130.
4. Cai Z, Blumbergs P, Cash K, Rice P, Manavis J, Swift J, Ghabriel M, Thompson P (2005) Paranodal pathology in Tangier disease with remitting-relapsing multifocal neuropathy. The XVIII World Congress of Neurology, 5-11 Nov 2005, Sydney, Australia, P333.
5. Cai Z, Finnie J, Manavis J, Ghabriel M, Thompson P, Blumbergs P (2005) Tomacula formation precedes segmental demyelination in an avian riboflavin deficiency model. The XVIII World Congress of Neurology, 5-11 Nov 2005, Sydney, Australia, P332.
6. Ghabriel M, Thomas A, Vink R (2005) Magnesium restores altered Aquaporin-4 immunoreactivity following traumatic brain injury to a preinjury state. Proceedings of 13th International Symposium on Brain oedema 2005, Michigan USA May 2005.
7. Howard C, Donkin J, Ghabriel M, Blumbergs P, Vink R (2004) A substance P antagonist increases aquaporin-4 expression and reduces oedema after traumatic brain injury. Proceedings of the 7th International Neurotrauma Symposium, Adelaide, Australia, September 2004, PA57.
8. Ghabriel MN, Zhu C, Imran AQ, Blumbergs PC, Reilly PL (2004) Blood-brain barrier ultrastructural changes in impact acceleration head trauma. Proceedings of the 7th International Neurotrauma Symposium, Adelaide, Australia, September 2004, PA61.
9. Cai Z, Blumbergs PC, Koblar S A, Cash K, Manavis J, Ghabriel MN, Thompson PD (2004) PNS and CNS pathology in rapidly progressive lower motor neurone syndrome with IgM anti-GM1 ganglioside antibody. Proceedings of the Australian Association of Neurologists, Perth May 10-14, 2004.
10. Ghabriel MN, Peppi M, Cai Z, Manavis J, Thompson PD, Blumbergs PC (2004) Heterogeneity of tight junctions in the rat sciatic nerve. Proceedings of the Australian Neuroscience Society 15: 157.
11. Peppi M, Ghabriel MN (2004) Differential distribution of tight junction proteins in the major salivary glands of the rat. Proceedings of the Australian Neuroscience Society 15: 158.
12. Lu JJ., Ghabriel MN, Tadros R, Hermanis G (2003) A narrow time window for opening of the blood-brain barrier in an immunological model. Proceedings of the Australian Neuroscience Society 14: Poster 390
13. Lu JJ, Ghabriel MN, Tadros R, Hermanis G, Magar P (2002) Time course of opening and closure of the blood-brain barrier following immunological targeting of the endothelial barrier antigen. Proceedings of the Third Asia Pacific Symposium on Neural Regeneration, December 2002, p. 72.
14. Lu JJ, Setchell BP, Ghabriel MN, Hermanis G, Zhu C (2002) Testicular endothelial cells express endothelial barrier antigen, previously thought to be specific to vessels in the central nervous system.  Proceedings of the 12th European Workshop on Molecular and Cellular Endocrinology of the Testis, The Netherlands, 6th-10th April2002, 4b-10.