Further Enquiries:
Discipline of Anatomical Sciences
The University of Adelaide
SA 5005
Email
Telephone: +61 8 8313 0530
Facsimile: +61 8 8303 5384
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 Professor
Emeritus Brian Setchell
BVSc (Sydney University)
PhD ScD (University of Cambridge)
Prof. Brian Setchell has a long-standing interest in the physiology, biochemistry,
and endocrinology of the testes and epididymis with particular reference to the
blood-testis barrier, testicular fluids and blood flow, the descent of the testis,
cryptorchidism and the effects of whole body or local heating of the testes on
sperm production, motility, fertilising ability, and the development of embryos
in normal females made pregnant by males whose testes had been heated.
Until the end of 1996, he was Professor of Animal Sciences in the Faculty of
Agricultural and Natural Resource Sciences at the Waite Campus and spent 1997-8
as a Nobel Foundation Fellow and 2000 as a STINT fellow at the Pediatric Endocrinology
Unit, Karolinska Hospital, Stockholm, Sweden. He has published a book "The
Mammalian Testis", and 69 major reviews and chapters in books, 136 original
research articles, and 203 abstracts on the work of his group on the testis
and epididymis, as well as translations of de Graaf's two books on Male and
Female Reproductive Organs (originally published in 1668 and 1672 respectively)
as well as of Sertoli's original 1865 article describing the cells in the testes
named after him. He was given the Distinguished Andrologist award for 1997 by
the American Society of Andrology.
Recent Publications
- Setchell BP, Pakarinen P and Huhtaniemi I (2002) How much LH do the Leydig cells see? Miniposter, 12th European Workshop on the Testis, 4a-13.
- Setchell BP, (2002) Innervation and vasculature of the excurrent duct system. In: The Epididymis: From Molecules fo Clinical Practice, Eds B Robaire and BT Hinton, New York, Kluwer Academic/Plenum, pp 35-48.
- Lu JJ, Setchell BP, Ghabriel MN, Hermanis G and Zhu C (2002) Testicular endothelial cells express endothelial barrier antigen previously thought to be specific to vessels in the central nervous system. Miniposter, 12th European Workshop on the Testis, 4b-10.
- Ghabriel MN, Lu JJ, Hermanis G, Zhu C and Setchell BP (2002) Expression of a blood-brain barrier specific antigen in the male reproductive tract. Reproduction 123, 389-397.
- Setchell BP, Ploen L and Ritzen EM (2002) Effect of local heating of rat testes after suppression of spermatogenesis by pretreatment with a GnRH agonist and antiandrogen. Reproduction, 124, 133-140.
- Setchell BP, Pakarinen P and Huhtaniemi I (2002) How much LH do the Leydig cells see. Journal of Endocrinology 175, 375-382.
- Gustafsson K, Sultana T, Zetterstrom CK, Setchell BP, Siddiqui A, Weber G and Soder O (2002) Production and secretion of interleukin-1a proteins by rat testis. Biochemical and Biophysical Research Communications 297, 492-497.
- Setchell BP, Hertel T and Soder O (2003) Postnatal testicular development, cellular organization and paracrine regulation. In: The Developing Testis. Physiology and Pathophysiology, ed O Soder, Basel, Karger, pp 24-37.
- Setchell BP (2004) Hormones: what the testis really sees. Reproduction, Fertility and Development. 16, 535-545.
- Zhu B, Walker SK, Oakey H, Setchell BP and Maddocks S (2004) Effect of paternal heat stress on the development in vitro of preimplantation embryos in the mouse. Andrologia 36, 384-394.
- Assmus M, Svechnikov K, von Euler M, Setchell BP, Sultana S, Zettterstrom C, Holst M, Kiess W and Soder O. (2004) Single subcutaneous administration of chorionic gonadotropin to rats induces a rapid and transient increase in testicular expression of pro-inflammatory cytokines. Pediatric Research 57, 896-901.
- Zhu BK and Setchell BP (2004) Effects of paternal heat stress on the in vivo development of preimplantation embryos in the mouse. Reproduction, Nutrition, Development 44, 617-629.
- Setchell BP and Palombi F. (2004) Isolation of endothelial cells from the rat testis, and their effect on testosterone secretion by interstitial cells. Miniposter, 13th European Workshop on the Testis, C6.
- Setchell BP and Breed WG (2005) Anatomy, vasculature and innervation of the male reproductive tract. In: The Physiology of Reproduction, Third edition, Ed. J.D.Neill, Elsevier, San Diego, pp 793-847.
- Zhu BK, Setchell BP, Walker SK and Maddocks S. (2005) Effect of a single exposure of males to high temperatures on embryos sired in normal female mice. Abstracts 3rd International Congress on Male-mediated Developmental Toxicity. C4.
- Ghabriel MH, Lu JJ, Lim WH and Setchell BP (2005) Effects of moderate spinal cord injury on the expression of a barrier marker in endothelial cell of the testis and in the prostate of rats. Reproduction, Fertility and Development 17 (Supplement) p 130. Abstract 305.
- Worawittayawong P, Leigh CM, Cozens G, Peirce EJ, Setchell BP, Sreratusa P, Dharmarajan A and Breed WG. (2005) Unusual germ cell organization in the seminiferous epithelium of a murid rodent from southern Asia, the greater bandicoot rat, Bandicota indica. International Journal of Andrology 28, 180-188.
- Lindsay DB, Barker PJ, Northrop AJ, Setchell BP, Faichney GJ. (2005) The recycling of carbon in glucose, lactate and alanine in sheep. Journal of Comparative Physiology [B] 175, 413-422.
- Strand M-L, Wahlgren A, Svechnikov K, Zetterstrom C, Setchell BP., and Soder O. (2006) Interleukin 18 is expressed in rat testis and may function as a host-defence factor. Molecular and Cellular Endocrinology 240, 64-73.
- Arman C, Quintana Casares PI, Sanchez-Partida LG, Setchell BP. (2006) Ram sperm motility after intermittent scrotal insulation evaluated by manual and computer-assisted methods. Asian Journal of Andrology 8, 411-418..
- Yaeram, J., Setchell, B.P., Maddocks, S. (2006) Effect of heat-stress of male mice on their fertility in vivo and in vitro. Reproduction Fertility Development 18, 647-653.
- Setchell BP. (2006) The effects of heat on the testes of mammals. Animal Reproduction 3, 81-90.
- de Rooij D. and Setchell BP. (2007) Long-term effects of a short period of moderately high testicular temperatures on rat spermatogenesis. Society for the Study of Reproduction Abstracts of Annual Meeting, Abstract no 72, p 92.
- Setchell BP (2007) Fluid exchange and transport of hydrophilic factors in the testis. In: The Leydig Cell in Health and Disease, Eds AH Payne and MP Hardy, Humana Press, Totowa NJ, pp 365-372.
- Setchell BP. (2008) Blood-testis barrier, junctional and transport proteins and spermatogenesis. In: Molecular Mechanisms in Spermatogenesis. Ed CY Cheng, Landes Bioscience (in press).
Other Publications of Interest
- BP Setchell (1978) "The Mammalian Testis" Elek Books,
London Cornell University Press, Ithaca. 450pp
- BP Setchell (1984) " Male Reproduction. Benchmark papers in
Human Physiology Volume 17. Van Nostrand Reinhold Comapny, New York 401pp
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